Protective effect of Aurelia aurita against free radicals and streptozotocin-induced diabetes

Authors

  • Mallikarjuna Rao Talluri AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530 003, Andhra Pradesh, India
  • Alekhya Ketha AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530 003, Andhra Pradesh, India
  • Ganga Rao Battu AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530 003, Andhra Pradesh, India
  • Rajananda Swamy Tadi AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530 003, Andhra Pradesh, India
  • Vinay Bharadwaj Tatipamula AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530 003, Andhra Pradesh, India http://orcid.org/0000-0002-9376-1911

DOI:

https://doi.org/10.3329/bjp.v13i3.36907

Keywords:

Aurelia aurita, Diabetes, Free radical

Abstract

The present work was carried out to identify the anti-oxidant and anti-diabetic activities of Aurelia aurita. The chemical profiling analysis showed that it possess different biologically active secondary metabolites like phenols, alakoids, steroids etc. The methanolic extract showed different free radical scavenging activity as ascorbic acid with  IC50 values 202, 205, 153 µg on DPPH, hydroxyl and superoxide free radicals. The extract significantly reduced the hyperglycemic conditions with percentage of reduction 18.7 ± 1.3 to 53.5 ±1.5 of streptozotocin-induced animals and the positive result of in-vitro aldose reductase enzyme inhibition with IC50 value 163 µg suggests that A. aurita have potential to cure the diabetic complications.

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Author Biographies

Mallikarjuna Rao Talluri, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530 003, Andhra Pradesh, India

Senior Analyst

Alekhya Ketha, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530 003, Andhra Pradesh, India

Research Scholar

Ganga Rao Battu, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530 003, Andhra Pradesh, India

Professor

Rajananda Swamy Tadi, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530 003, Andhra Pradesh, India

Assistant Professor

Vinay Bharadwaj Tatipamula, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530 003, Andhra Pradesh, India

Research Scholar

Published

2018-09-28

How to Cite

Talluri, M. R., A. Ketha, G. R. Battu, R. S. Tadi, and V. B. Tatipamula. “Protective Effect of Aurelia Aurita Against Free Radicals and Streptozotocin-Induced Diabetes”. Bangladesh Journal of Pharmacology, vol. 13, no. 3, Sept. 2018, pp. 287-95, doi:10.3329/bjp.v13i3.36907.

Issue

Section

Research Articles