Hypoglycemic potential of Elaeagnus angustifolia fruit polysaccharide on streptozotocin-induced type 2 diabetic mice

Authors

  • Ya Wang School of Life Science and Engineering, Lanzhou University of Technology Lan Gong Ping Street 287, Lanzhou 730050, China
  • Hongmei Zou School of Life Science and Engineering, Lanzhou University of Technology Lan Gong Ping Street 287, Lanzhou 730050, China
  • Cui Sun School of Life Science and Engineering, Lanzhou University of Technology Lan Gong Ping Street 287, Lanzhou 730050, China
  • Tao Guo School of Life Science and Engineering, Lanzhou University of Technology Lan Gong Ping Street 287, Lanzhou 730050, China
  • Zaiping Feng School of Life Science and Engineering, Lanzhou University of Technology Lan Gong Ping Street 287, Lanzhou 730050, China

DOI:

https://doi.org/10.3329/bjp.v13i4.37069

Keywords:

Diabetes, Elaeagnus angustifolia, Mice

Abstract

In this study, the hyperglycemic potential of Elaeagnus angustifolia fruit polysaccharide in both normal healthy and streptozotocin-induced diabetic mice was investigated. Results showed no significant effect of E. angustifolia fruit polysaccharide on blood glucose level in normal control group, while E. angustifolia significantly suppressed the rise in blood glucose of diabetic mice. In addition, in the first two weeks of administration, the body weight was decreased both in negative control group and E. angustifolia groups, however, E. angustifolia  (800 mg/kg) was recovered to the began weight in the fourth week. E. angustifolia (800 mg/kg) could markedly reduce the levels of total cholesterol, triglyceride and improve the level of high density lipoprotein-cholesterol. The results suggest that E. angustifolia could be considered as an ingredient of functional foods for diabetes.

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Published

2018-10-07

How to Cite

Wang, Y., H. Zou, C. Sun, T. Guo, and Z. Feng. “Hypoglycemic Potential of Elaeagnus Angustifolia Fruit Polysaccharide on Streptozotocin-Induced Type 2 Diabetic Mice”. Bangladesh Journal of Pharmacology, vol. 13, no. 4, Oct. 2018, pp. 297-01, doi:10.3329/bjp.v13i4.37069.

Issue

Vol. 13 No. 4 (2018)

Section

Research Articles

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