Efficacy and safety of novel oral anticoagulants versus vitamin K antagonists in the treatment of venous thromboembolism

Authors

  • Maodi Xu Department of Clinical Pharmacy, Yijishan Hospital of Wannan Medical College, Anhui Provincial Center for Drug Clinical Evaluation, Wuhu, Anhui 241001, China
  • Qingquan Xue Department of Vascular Surgery, Yijishan Hospital, Wannan Medical College, Wuhu, Anhui 241001, China
  • Zhichen Pu Department of Clinical Pharmacy, Yijishan Hospital of Wannan Medical College, Anhui Provincial Center for Drug Clinical Evaluation, Wuhu, Anhui 241001, China
  • Zijing Wu Department of Clinical Pharmacy, Yijishan Hospital of Wannan Medical College, Anhui Provincial Center for Drug Clinical Evaluation, Wuhu, Anhui 241001, China
  • Haitang Xie Department of Clinical Pharmacy, Yijishan Hospital of Wannan Medical College, Anhui Provincial Center for Drug Clinical Evaluation, Wuhu, Anhui 241001, China

DOI:

https://doi.org/10.3329/bjp.v13i3.37124

Abstract

The aim of this meta-analysis was to systematically evaluate the efficacy and safety of novel oral anticoagulants and vitamin K antagonists in the treatment of venous thromboembolism. A total of 6 studies met the inclusion criteria and a total of 19,350 patients with venous thromboembolism were included. Among them, rivaroxaban (3 RCTs, n=90/3,449/4,832); dabigatran (2 RCTs, n=200/2,539); edoxaban (1 RCT, n=8,240). The results of meta-analysis showed that the total bleeding rate after treatment with the vitamin K antagonist group was higher than with the new oral anticoagulant group (OR=0.82, 95% confidence interval 0.75-0.90, p<0.0001), and the difference was highly statistically significant. Overall, new oral anticoagulants are compara-ble to vitamin K antagonists, but new oral anticoagulants can reduce the occurrence of bleeding events and the safety was superior to vitamin K antagonists.

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Published

2018-09-14

How to Cite

Xu, M., Q. Xue, Z. Pu, Z. Wu, and H. Xie. “Efficacy and Safety of Novel Oral Anticoagulants Versus Vitamin K Antagonists in the Treatment of Venous Thromboembolism”. Bangladesh Journal of Pharmacology, vol. 13, no. 3, Sept. 2018, pp. 273-9, doi:10.3329/bjp.v13i3.37124.

Issue

Section

Meta-Analysis