In vitro antioxidant, hypotensive and diuretic activities of Origanum glandulosum in rat

Authors

  • Amel Bouaziz Laboratory of Phytotherapy Applied to Chronic Diseases, Department of Biology and Animal Physiology, Faculty of Nature and Life Sciences, University Setif 1, Setif, 19000, Algeria. https://orcid.org/0000-0002-3265-6659
  • Seddik Khennouf Faculty of Nature and Life Sciences, University Setif 1, Setif, 19000, Algeria.
  • Musa Abu Zarga Department of chemistry, Faculty of science, the University of Jordan, Amman, Jordan.
  • Shtaywy Abdalla Department of Biology, Faculty of Science, the University of Jordan, Amman, Jordan

DOI:

https://doi.org/10.3329/bjp.v14i1.38089

Keywords:

Anti-oxidant, Diuretic, Hypotensive, In vitro, Origanum glandulosum, Rat

Abstract

The objective of this study was to evaluate the in vitro antioxidant, hypotensive and the diuretic activities of Origanum glandulosum leaves in rat. Chemical analysis revealed the isolation of katuranin and 5-isopropyl-3-methylphenol. Ethyl acetate extract possessed highest scavenging activity against DPPH and hydroxyl radicals. Intravenous administration of extracts (0.04 to 12 mg/kg body weight) dose-dependently decreased the blood pressure (systolic, diastolic and mean) of the anesthetized rat. Methanol extract showed dose-dependent diuretic activity by increasing the urine output (77%) and the urinary excretion of sodium and potassium. In conclusion, this study supports the use of O. glansulosum in traditional medicine as hypotensive and diuretic agents.

Video Clip of Methodology:

DPPH radical scavenging assay: 4 min 45 sec: Click to watch

Downloads

Download data is not yet available.
Abstract
56
Download
29 Read
7

Author Biographies

Seddik Khennouf, Faculty of Nature and Life Sciences, University Setif 1, Setif, 19000, Algeria.

Laboratory of Phytotherapy Applied to Chronic Diseases, Department of Biology and Animal Physiology, Faculty of Nature and Life Sciences, University Setif 1, Setif, 19000, Algeria.

Musa Abu Zarga, Department of chemistry, Faculty of science, the University of Jordan, Amman, Jordan.

 Natural products laboratory, Department of chemistry, Faculty of science, the University of Jordan, Amman, Jordan.

Shtaywy Abdalla, Department of Biology, Faculty of Science, the University of Jordan, Amman, Jordan

Animal & Human Physiology Laboratory, Department of Biology, Faculty of Science, the University of Jordan, Amman, Jordan

Downloads

Additional Files

Published

2019-01-20

How to Cite

Bouaziz, A., S. Khennouf, M. Abu Zarga, and S. Abdalla. “In Vitro Antioxidant, Hypotensive and Diuretic Activities of Origanum Glandulosum in Rat”. Bangladesh Journal of Pharmacology, vol. 14, no. 1, Jan. 2019, pp. 17-25, doi:10.3329/bjp.v14i1.38089.

Issue

Vol. 14 No. 1 (2019)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).