In vivo anti-diabetic effect of aqueous and methanolic macerated extracts of Atractylis gummifera

Authors

  • Khadija Bouabid Laboratory of Materials, Natural Substances, Environment and Modeling, Polydisciplinary Faculty of Taza, Sidi Mohamed Ben Abdellah University of Fez B. P., 1223 Taza-Gare, Taza https://orcid.org/0000-0002-4522-9576
  • Fatima Lamchouri Laboratory of Materials, Natural Substances, Environment and Modeling (LMSNEM), Polydisciplinary Faculty of Taza, Sidi Mohamed Ben Abdellah University of Fez Morocco. http://orcid.org/0000-0002-6711-1050
  • Hamid Toufik Laboratory of Materials, Natural Substances, Environment and Modeling, Polydisciplinary Faculty of Taza, Sidi Mohamed Ben Abdellah University of Fez B. P., 1223 Taza-Gare, Taza https://orcid.org/0000-0001-7213-6909
  • Mohamed Boulfia Laboratory of Materials, Natural Substances, Environment and Modeling, Polydisciplinary Faculty of Taza, Sidi Mohamed Ben Abdellah University of Fez B. P., 1223 Taza-Gare, Taza https://orcid.org/0000-0003-2862-6083
  • Souad Senhaji Laboratory of Materials, Natural Substances, Environment and Modeling, Polydisciplinary Faculty of Taza, Sidi Mohamed Ben Abdellah University of Fez B. P., 1223 Taza-Gare, Taza https://orcid.org/0000-0001-8649-7457
  • My El Abbes Faouzi Laboratory of Pharmacology and Toxicology, Pharmacokinetics Research Team, Faculty of Medicine and Pharmacy, Mohammed V University, BP 6203, Rabat-Institutes, Rabat https://orcid.org/0000-0003-3863-4677

DOI:

https://doi.org/10.3329/bjp.v14i2.38870

Keywords:

Atractylis gummifera L., Aqueous macerate, Diabetes mellitus

Abstract

The anti-diabetic effect of Atractylis gummifera (plant used in traditional Moroccan medicine) has been evaluated in type 2 diabetic mice model. The mice were divided into five groups: Normal control, diabetic control, diabetic treated with aqueous macerate (500 mg/kg), diabetic treated with methanol macerate (500 mg/kg) and diabetic treated with metformin (300 mg/kg). The treatment of the mice was performed by daily gastric gavage for 5 weeks. The monitoring of the mice was carried out weekly by fasting glucose and measurement of biochemical parameters at the end of treatment. The aqueous macerate of A. gummifera was most effective that reduced the fasting blood glucose with 62.7%. In addition, this extract restored the biochemical parameters of diabetic mice to normal.

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Published

2019-04-14

How to Cite

Bouabid, K., F. Lamchouri, H. Toufik, M. Boulfia, S. Senhaji, and M. E. A. Faouzi. “In Vivo Anti-diabetic effect of Aqueous and Methanolic Macerated Extracts of Atractylis Gummifera”. Bangladesh Journal of Pharmacology, vol. 14, no. 2, Apr. 2019, pp. 67-73, doi:10.3329/bjp.v14i2.38870.

Issue

Vol. 14 No. 2 (2019)

Section

Research Articles

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