Berberine hydrochloride inhibits inflammatory response via regulating the miRNA-140-5p/TLR4/NF-κB signaling pathway in oral lichen planus

Authors

  • Qiong Zhang Department of Stomatology, The Affiliated Hospital of Hangzhou Normal Hospital, No. 126, Wenzhou Road, Hangzhou 310015, Zhejiang Province, China.
  • Liangjun Zhong Department of Stomatology, The Affiliated Hospital of Hangzhou Normal Hospital, No. 126, Wenzhou Road, Hangzhou 310015, Zhejiang Province, China.
  • Xing Chen Department of Stomatology, The Affiliated Hospital of Hangzhou Normal Hospital, No. 126, Wenzhou Road, Hangzhou 310015, Zhejiang Province, China.
  • Jintao Wang Department of Stomatology, The Affiliated Hospital of Hangzhou Normal Hospital, No. 126, Wenzhou Road, Hangzhou 310015, Zhejiang Province, China.

DOI:

https://doi.org/10.3329/bjp.v15i2.43513

Keywords:

Berberine hydrochloride, Inflammation, miRNA-140-5p, Oral lichen planus, TLR4

Abstract

The present study investigates the anti-inflammatory mechanism of berberine hydrochloride in the oral lichen planus. The local inflammatory environment of the oral lichen planus was mimicked, through which lipopolysaccharides stimulated keratinocyte HaCaT cells. Berberine hydrochloride suppressed the activation of the TLR4/NF-κB inflammatory signaling pathway by up-regulating miRNA-140-5p, which is an independent risk factor for the oral lichen planus. Furthermore, miRNA-140-5p inhibited the TLR4/NF-κB inflammatory signaling pathway by directly suppressing TLR4 expression. Therefore, the present study suggests that berberine hydrochloride inhibits the inflammatory response by up-regulating miRNA-140-5p to suppress the activation of the TLR4/NF-κB inflammatory signaling pathway in the oral lichen planus.

Video Clip of Methodology

RNA mixed with template: 2 min 17 sec:  Click to Watch

Scrubbing and fixing glue device: 3 min 13 sec: Click to Watch

Downloads

Download data is not yet available.
Abstract
59
Download
28

Downloads

Published

2020-07-04

How to Cite

Zhang, Q., L. Zhong, X. Chen, and J. Wang. “Berberine Hydrochloride Inhibits Inflammatory Response via Regulating the MiRNA-140-5p/TLR4/NF-κB Signaling Pathway in Oral Lichen Planus”. Bangladesh Journal of Pharmacology, vol. 15, no. 2, July 2020, pp. 58-68, doi:10.3329/bjp.v15i2.43513.

Issue

Vol. 15 No. 2 (2020)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).