Berberine hydrochloride inhibits inflammatory response via regulating the miRNA-140-5p/TLR4/NF-κB signaling pathway in oral lichen planus

Authors

  • Qiong Zhang Department of Stomatology, The Affiliated Hospital of Hangzhou Normal Hospital, No. 126, Wenzhou Road, Hangzhou 310015, Zhejiang Province, China.
  • Liangjun Zhong Department of Stomatology, The Affiliated Hospital of Hangzhou Normal Hospital, No. 126, Wenzhou Road, Hangzhou 310015, Zhejiang Province, China.
  • Xing Chen Department of Stomatology, The Affiliated Hospital of Hangzhou Normal Hospital, No. 126, Wenzhou Road, Hangzhou 310015, Zhejiang Province, China.
  • Jintao Wang Department of Stomatology, The Affiliated Hospital of Hangzhou Normal Hospital, No. 126, Wenzhou Road, Hangzhou 310015, Zhejiang Province, China.

DOI:

https://doi.org/10.3329/bjp.v15i2.43513

Keywords:

Berberine hydrochloride, Inflammation, miRNA-140-5p, Oral lichen planus, TLR4

Abstract

The present study investigates the anti-inflammatory mechanism of berberine hydrochloride in the oral lichen planus. The local inflammatory environment of the oral lichen planus was mimicked, through which lipopolysaccharides stimulated keratinocyte HaCaT cells. Berberine hydrochloride suppressed the activation of the TLR4/NF-κB inflammatory signaling pathway by up-regulating miRNA-140-5p, which is an independent risk factor for the oral lichen planus. Furthermore, miRNA-140-5p inhibited the TLR4/NF-κB inflammatory signaling pathway by directly suppressing TLR4 expression. Therefore, the present study suggests that berberine hydrochloride inhibits the inflammatory response by up-regulating miRNA-140-5p to suppress the activation of the TLR4/NF-κB inflammatory signaling pathway in the oral lichen planus.

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Published

2020-07-04

How to Cite

Zhang, Q., L. Zhong, X. Chen, and J. Wang. “Berberine Hydrochloride Inhibits Inflammatory Response via Regulating the MiRNA-140-5p/TLR4/NF-κB Signaling Pathway in Oral Lichen Planus”. Bangladesh Journal of Pharmacology, vol. 15, no. 2, July 2020, pp. 58-68, doi:10.3329/bjp.v15i2.43513.

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Section

Research Articles