Efficacy of beta-blockers in the treatment of sepsis

Authors

  • Peng Jin Department of Critical Care Medicine, Hangzhou Fuyang Hospital of Traditional Chinese Medicine, Hangzhou, China.
  • Tao Zhao Department of Critical Care Medicine, Hangzhou Fuyang Hospital of Traditional Chinese Medicine, Hangzhou, China.
  • Yueyue Wei Department of Critical Care Medicine, Hangzhou Fuyang Hospital of Traditional Chinese Medicine, Hangzhou, China.
  • Fang Zhao Department of Emergency Intensive Care Unit, Zhuji Affiliated Hospital of Shaoxing University, Shaoxing, China.

DOI:

https://doi.org/10.3329/bjp.v16i1.46001

Keywords:

Beta-blocker, Meta-analysis, Sepsis

Abstract

This meta-analysis is to systematically evaluate the efficacy and safety of beta-blockers in the treatment of sepsis. A total of 17 articles that met the inclusion criteria were included, and 10,385 cases were obtained. The meta-analysis results showed that patients with sepsis with beta-blocker usage had a significantly lower 28-day mortality. The heart rate decreased over time in patients with sepsis using beta-blocker. Moreover, central venous blood oxygen saturation increased after 24, 48, 72 hours of treatment; lactic acid and cardiac troponin I decreased after 48, 72 hours of treatment; and tumor necrosis factor-α, interleukin-1β levels decreased significantly after 12, 24, 48, 72 hours of treatment (p<0.05).  In conclusion, beta-blockers reduce 28-day mortality and heart rate.

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Published

2021-01-03

How to Cite

Jin, P., T. Zhao, Y. Wei, and F. Zhao. “Efficacy of Beta-Blockers in the Treatment of Sepsis”. Bangladesh Journal of Pharmacology, vol. 16, no. 1, Jan. 2021, pp. 1-18, doi:10.3329/bjp.v16i1.46001.

Issue

Section

Meta-Analysis