Alpha-tocopherol reduces oxidative stress in perinatal asphyxia

Authors

  • Rashidul Karim Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka 1000, Bangladesh.
  • M. A. Mannan Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka 1000, Bangladesh.

DOI:

https://doi.org/10.3329/bjp.v1i1.480

Keywords:

Oxidative stress, Perinatal asphyxia, alpha-Tocopherol

Abstract

Twenty asphyxiated neonates were studied by estimating reduced gluthathione (GSH) level in red blood cell (RBC) to assess the level of oxidative stress. Neonates were randomly divided into two groups. One group received ?-tocopherol (10 mg/kg body weight) once orally daily for 5 days and other group received only vehicle. The mean (± SD) value of GSH in RBC within 24 hrs of age of asphyxiated neonates was 12.26 ± 4.29 mg/dL in untreated group and 11.97 ± 2.34 mg/dL in treated group. After 5 days of asphyxiated neonates (in ?-tocopherol untreated group) the GSH level increased to 14.45 ± 3.46 mg/dL whereas in asphyxiated neonates treated with ?-tocopherol, it increased to 25.65 ± 4.99 mg/dL indicating 5 days treatment with ?-tocopherol among asphyxiated neonates caused approximately two fold increase in GSH level which was statistically significant (P<0.001). This study suggests that ?-tocopherol may be useful to reduce the oxidative stress in patients of perinatal asphyxia.

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How to Cite

Karim, R., and M. A. Mannan. “Alpha-Tocopherol Reduces Oxidative Stress in Perinatal Asphyxia”. Bangladesh Journal of Pharmacology, vol. 1, no. 1, June 2006, pp. 5-9, doi:10.3329/bjp.v1i1.480.

Issue

Vol. 1 No. 1 (2006)

Section

Research Articles

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