Synthesis of some bis-triazole derivatives as probes for cytotoxicity study

Authors

  • Mohammad Al-Amin Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
  • M. Rabiul Islam Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.

DOI:

https://doi.org/10.3329/bjp.v1i1.483

Keywords:

bis-Triazole, Cytotoxicity, Shrimp

Abstract

A series of bis[4-N-amino-5-mercapto-1,2,4-triazol-3-yl] alkanes (1a-e) and their Schiff bases with 2-adamanta-none (2a-d) and bis [1, 2, 4-triazolo [3, 4-b] - 1, 3, 4-thiadiazol-4-yl] alkanes (3a-e) have been synthesized with high yields. The cytotoxicity study of these newly synthesized compounds against brine shrimp lethality test as well as Structure-Activity-Relationship (SAR) has been discussed.

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References

Andotra CS, Sharma SK. In the synthesis of new 1,3,4-oxazdiazole and 1,2,4-triazole derivatives. Ind J Pharm Sci. 1989; 51: 107

Heindel ND, Reid JR. 4-Amino-3-mercapto-4H-1,2,4,-triazoles and propargyl aldehydes: a new route to 3-R-8-Aryl-1,2,4-triazolo [3,4-b]-1,3,4-thiadiazepines. J Heterocycl Chem. 1980; 17: 1087-88.

Hirota T, Sasaki K, Yamamoto H, Nakayama T. Polycyclic N-hetero compounds. 91XVI. Syntheses and antidepressive evaluation of 11,13,15,17-tetraazasteroids and their 17-oxides. J Heterocycl Chem. 1991; 28: 257-61.

Lubrizol Corp, US Pat, 4, 246, 126 (1981).

Meyer BN, Ferringni NR, Putnam JE, Jacobsen LB, Nichols DE, Mclaughlin JL. Brine shrimp: A convenient general bioassay for bioactive plant constituents. Planta Medica. 1982; 45: 31-34.

Omar AMME, Aboul Wafa OM. Synthesis and in vitro antimicrobial and antifungal properties of some novel 1,3,4,thiadiazole and s-triazole[3,4-b][1,3,4]thiadiazole derivatives. J Heterocycl Chem. 1986; 23: 1339-41.

Shivarama Holla B, Gonsalves R, Shenoy S. Studies on some N-bridged heterocycles derived from bis-[4-amino-5-mercapto-1,2,4-triazol-3-yl]alkanes. Farmaco 1988; 53: 574-78.

Yale HL, Piala JJ. Substituted s-triazoles and related compounds. J Med Chem. 1966; 9: 42-46.

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How to Cite

Al-Amin, M., and M. R. Islam. “Synthesis of Some Bis-Triazole Derivatives As Probes for Cytotoxicity Study”. Bangladesh Journal of Pharmacology, vol. 1, no. 1, June 2006, pp. 21-26, doi:10.3329/bjp.v1i1.483.

Issue

Vol. 1 No. 1 (2006)

Section

Research Articles

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