Hypolipidemic effects of fenugreek seed powder

Authors

  • Abu Saleh M. Moosa Department of Pharmacology, Rajshahi Medical College, Rajshahi
  • Mamun Ur Rashid Department of Pharmacology, Rajshahi Medical College, Rajshahi
  • A. Z. S. Asadi Department of Pharmacology, Rajshahi Medical College, Rajshahi
  • Nazma Ara Department of Pharmacology, Rajshahi Medical College, Rajshahi
  • M. Mojib Uddin Department of Pharmacy, University of Dhaka, Dhaka 1000
  • A. Ferdaus Department of Pharmacy, University of Dhaka, Dhaka 1000

DOI:

https://doi.org/10.3329/bjp.v1i2.490

Keywords:

Fenugreek, Hypolipidemic effect

Abstract

Effects of fenugreek (Trigonella foenugraecum Linn) on serum lipid profile in hypercholesteremic type 2 diabetic patients were studied. Administration of fenugreek seed powder of 25 g orally twice daily for 3 weeks and 6 weeks produces significant (p<0.001) reduction of serum total cholesterol, triacylglyceride and LDL-cholesterol in hypercholesteremic group but the change of serum HDLcholesterol was not significant. On other hand, changes of lipid profile in hypercholesteremic type 2 diabetic patients without fenugreek were not significant (p<0.001). The present study suggests that fenugreek seed powder would be considered as effective agent for lipid lowering purposes.  

Downloads

Download data is not yet available.
Abstract
287
Download
722 Read
2

References

Al-Habori M, Al-Aghban AM, Al-Mamary M. Effect of fenugreek seeds and its extracts on plasma lipid profile: A study on rabbits. Phytotherapy Res. 1998; 12: 572-75.

Awal MA, Rashid MU, Ahmed KW, Asadi ZS, Islam K. Effect of karela and fenugreek on lipid profile in hypocholesterolemic diabetic patients. Bangladesh J Physiol Pharmacol. 1999; 15: 6-8.

Basch E, Ulbricht C, Kuo G, Szapary P, Smith M. Therapeutic applications of fenugreek. Altern Med Rev. 2003; 8: 20-27.

Mahley RW, Bersot TP. Drug therapy for hypercholesterolemia and dyslipidemia. In: Goodman & Gilman's The pharmacological basis of therapeutics. Hardman JG and Limbird LE (eds). 10th edi, New York, McGraw-Hill, 2001, pp 971-1002.

Florey CD, Medonald H, Miall W. Serum lipids and their relations to blood glucose in cardiovascular measurements in rural population of Jamaican adults. J Chronic Dis. 1973; 26-85.

Powers AC. Diabetes mellitus. In: Harrisons Principles of internal medicine. Kasper et al. (eds). 16th ed, New York, McGraw-Hill, 2005, pp 2152-80.

James H, Atrovastatin reduces remnant lipoproteins and small, dense low-density lipoprteins regardless of the baseline lipid pattern. Prev Cardiol. 2004; 7: 154-60.

Jensen R. Fenugreek, overlooked but not forgotten. UCLA Lactation Alumni Newsletter. 1992; 1: 2-3.

Prasanna M. Hypolipidemic effect of fenugreek: A clinical study. Indian J Pharm. 2000; 32: 34-6.

Sharma RD. Effects of fenugreek seeds and leaves on blood glucose and serum insulin responses in human subjects. Nutr Res. 1986; 6: 1353-64.

Sharma RD, Raghuram TC. Hypoglycaemic effect of fenugreek seeds in non-insulin dependent diabetic subjects. Nutr Res. 1990; 10: 731-39.

Sharma RD. Hypocholesterolemic activity of fenugreek an experimental study in rat. Nutr Rep Int. 1984; 30: 221-31.

Stancu C, Sima A. Statin: Mechanism of action and effects. Nicolae Simionescu Institute of Cellular Biology and Pathology, Bucharest, Romania, 2001.

Downloads

Additional Files

How to Cite

Moosa, A. S. M., M. U. Rashid, A. Z. S. Asadi, N. Ara, M. M. Uddin, and A. Ferdaus. “Hypolipidemic Effects of Fenugreek Seed Powder”. Bangladesh Journal of Pharmacology, vol. 1, no. 2, Dec. 2006, pp. 64-67, doi:10.3329/bjp.v1i2.490.

Issue

Vol. 1 No. 2 (2006)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).