Synthesis of isatin, 5-chloroisatin and their &Delta;<sup>2</sup>-1,3,4 oxadiazoline derivatives for comparative cytotoxicity study on brine shrimp

Authors

  • Md. Rabiul Islam Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342
  • Mohammad Mohsin Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342

DOI:

https://doi.org/10.3329/bjp.v2i1.494

Keywords:

Chloroisatin, Cytotoxicity, Oxadiazoline

Abstract

Isatin (3a), isatin 3-carbohydrazone (4a), 5-spiro (isatin) 2-(N-acetyl hydra-zino) 4-(N-acetyl)-?2-1,3,4 oxadiazoline (5a), and 5-spiro (isatin) 2-hydrazino-?2-1,3,4 oxadiazoline (6a) had been synthesized from the unsubstituted oximinoacetanilide (2a). 4-Chlorooximinoacetanilide (2b), 5-chloroisatin (3b), 5-chloroisatin 3-carbohydrazone (4b) and 5-spiro (5¢-chloroisatin) 2-(N-acetyl hydrazino) 4-N-acetyl ?2-1,3,4 oxadiazoline (5b) compounds had been synthesized from p-chloroaniline. The structures of the products had been characterized from the spectral analysis and comparative cytotoxicity study of them was studied.

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References

Islam MR, Khayer K, Shaha G, Chowdhury MSK. Syntheses of thiocarbohydrazide, some thiocarbo-hydrazones and their cyclized products as probes for pharmacological studies. Indian. J Chem. 1992; 31B: 547.

Islam MR, Khayer K, Abedin MJ. Reaction of isatin with 2-aminophenol leading to spiroheterocycles having anticancer activity. Jahangirnagar Univ J Sci. 2001; 24: 17.

Lingcon MH, Islam R, Khayer K, Islam MR. Cyclization of substituted indole-2-one-3-thiosemicarbazones to noble heterocyclic systems. J Bangladesh Chem Soc. 2001; 14: 127.

Islam R. Indian. J Chem. 2001; 40B: 240.

Kubota S, Yasufumi U, Fujikane K, Toyooka K, Shibuya M. Synthesis of 4-acyl-2-(acylamino)-D2-1,3,4-thiadiazolines and 4-acyl-2-amino-D2-1,3,4-thiadiazolines by acylation of thiosemicarbazones. J Org Chem. 1980; 45: 1473.

Islam MR, Khayer K, Islam R. Jahangirnagar Univ J Sci. 1997; 21: 1.

Microwell A. Cytotoxicity assay using Artemia salina (brine shrimp). Planta Med. 1997; 59: 250.

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How to Cite

Islam, M. R., and M. Mohsin. “Synthesis of Isatin, 5-Chloroisatin and Their &Delta;<sup>2</Sup>-1,3,4 Oxadiazoline Derivatives for Comparative Cytotoxicity Study on Brine Shrimp”. Bangladesh Journal of Pharmacology, vol. 2, no. 1, June 2007, pp. 7-12, doi:10.3329/bjp.v2i1.494.

Issue

Vol. 2 No. 1 (2007)

Section

Research Articles

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