In vitro study of antiamoebic effect of methanol extract of mature seeds of Carica papaya on trophozoites of Entamoeba histolytica
DOI:
https://doi.org/10.3329/bjp.v5i1.5003Keywords:
Amoebiasis, Entamoeba histolytica, Carica papayaAbstract
Antiamoebic activity of methanol extract of mature seeds of Carica papaya was tested in vitro on axenic culture of Entamoeba histolytica using metronidazole as a reference amoebicidal agent. The MIC of seed extract was >62.5 µg/mL as compared to <0.8 µg/mL for metronidazole. The present study suggests that the mature seeds of C. papaya have antiamoebic effect but less pronounced than metronidazole.
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References
Andrews JM. Determination of minimum inhibitory concentrations. J Antimicrob Chemother. 2001; 48: 5-16.
Bansal D, Sehgal R, Chawla Y, Malla N, Mahajan RC. Multidrug resistance in amoebiasis patient. Indian J Med Res. 2006; 124: 189-94.
Calzada F, Yepez-mulia L, Aguilar A. In vitro susceptibility of Entamoeba histolytica and Giardia lamblia to plants used in Mexican traditional medicine for the treatment of gastrointestinal disorders. J Ethnopharmacol. 2006; 108: 367-70.
Clark CG, Diamond LS. Methods for cultivation of luminal parasitic protists of clinical importance. Clin Microbiol Rev. 2002; 15: 329-41.
Ghani A. Carica papaya (Linn). In: Ghani A, (ed). Medicinal plants of Bangladesh with chemical constituents. 2nd ed. Dhaka, Asiatic Society of Bangladesh, 2003, p149.
Krishna KL, Paridhavi M, Patel JA. Review on nutritional, medicinal and pharmacological properties of papaya (Carica papaya Linn.). Nat Prod Radian. 2008; 7: 364-73.
Lakshmi V, Saxena A, Mishra SK, Mishra M, Srivastava S, Ghoshal S. Antiamoebic activity of marine sponge Haliclona exigua (Krikpatrick). Bangladesh J Pharmacol. 2009; 4: 55-59.
Tona L, Kambu K, Ngimbi N, Cimanga K, Vlietinck AJ. Antiamoebic and phytochemical screening of some Congolese medicinal plants. J Ethnopharmacol. 1998; 61: 57-65.
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