Expression of HOXC10 gene regulates the growth and invasion of prostate cancer cells

Authors

  • Hongmei Song Department of Interventional Radiology, Shanghai Sixth People's Hospital East Affiliated to Shanghai University of Medicine and Health Science, Shanghai 201306, China.
  • Xuxiao Ye Department of Urology, Shanghai Sixth People's Hospital East Affiliated to Shanghai University of Medicine and Health Science, Shanghai 201306, China.
  • Tao Liang Department of Urology, Shanghai Sixth People's Hospital East Affiliated to Shanghai University of Medicine and Health Science, Shanghai 201306, China.
  • Dongliang Yan Department of Urology, Shanghai Sixth People's Hospital East Affiliated to Shanghai University of Medicine and Health Science, Shanghai 201306, China.
  • Zuowei Li Department of Urology, Shanghai Sixth People's Hospital East Affiliated to Shanghai University of Medicine and Health Science, Shanghai 201306, China.

DOI:

https://doi.org/10.3329/bjp.v16i1.50244

Keywords:

HOXC10 gene, Prostate cancer cell

Abstract

The present study was undertaken to decipher the role of HOXC10 gene in regulating the growth and metastasis of prostate cancer. The results revealed significant (p<0.05) up-regulation of HOXC10 gene in human prostate cancer tissues and cell lines. The silencing of HOXC10 transcript level significantly (p<0.05) inhibited the growth and colony formation of DU145 and 22Rv1 prostate cancer cells. The DAPI staining revealed that inhibition of DU145 and 22Rv1 prostate cancer cell viability was due to the induction of apoptosis. The transwell assay showed that HOXC10 significantly (p<0.05) inhibits the invasion of prostate cancer cells. The Western blotting revealed that HOXC10 gene exerts its effects via modulation of Ras/Raf/MEK/ERK signaling cascade. Collectively, the results point towards the therapeutic potential of HOXC10 in the treatment of prostate cancer.

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Published

2021-01-04

How to Cite

Song, H., X. Ye, T. Liang, D. Yan, and Z. Li. “Expression of HOXC10 gene regulates the growth and invasion of prostate cancer Cells”. Bangladesh Journal of Pharmacology, vol. 16, no. 1, Jan. 2021, pp. 19-26, doi:10.3329/bjp.v16i1.50244.

Issue

Section

Research Articles