Wound healing properties of the protein kinase A inhibitor and the mechanisms of their development

  • Gleb N. Zyuz`kov Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia, 3 Lenin Prospect, Tomsk, 634028, Russia.
  • Larisa A. Miroshnichenko Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia, 3 Lenin Prospect, Tomsk, 634028, Russia. http://orcid.org/0000-0002-3684-5510
  • Tatyana Yu Polyakova Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia, 3 Lenin Prospect, Tomsk, 634028, Russia. http://orcid.org/0000-0003-0971-7844
  • Larisa A. Stavrova Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia, 3 Lenin Prospect, Tomsk, 634028, Russia. http://orcid.org/0000-0002-4729-6406
  • Elena V. Simanina Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia, 3 Lenin Prospect, Tomsk, 634028, Russia. http://orcid.org/0000-0003-1890-6946
Keywords: Microenvironment cell, Protein kinase A, Progenitor cell, Regenerative medicine, Skin wound

Abstract

The regenerative activity of the protein kinase A inhibitor was investigated using externally on the model of the flap skin wound. The pronounced wound healing effects of the protein kinase A inhibitor had been revealed. They are based on the activation of mesenchymal progenitor cells. The development of this phenomenon was associated with the direct influence of the protein kinase A inhibitor on mesenchymal progenitor cells. The most significant stimulation of their growth potential occurred in the context of the impact of growth factors in particular fibroblast growth factor secreted by the stromal cells. Moreover, in situ, there was an increase not only in proliferating activity but also in the intensity of the specialization processes of progenitors. Without cytokines stimulation, the change in the pattern of cellular cAMP-mediated signal does not affect the maturation rate of precursors.

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Published
2021-04-01
How to Cite
Zyuz`kovG., L. Miroshnichenko, T. Polyakova, L. Stavrova, and E. Simanina. “Wound Healing Properties of the Protein Kinase A Inhibitor and the Mechanisms of Their Development”. Bangladesh Journal of Pharmacology, Vol. 16, no. 2, Apr. 2021, pp. 34-41, doi:10.3329/bjp.v16i2.50575.
Section
Research Articles