Antibacterial activity of Cathormion umbellatum
Keywords:Antibacterial activity, Antibiotic-Resistant Bacteria, Cathormion umbellatum
The aim of this study was to determine the antibacterial activity of Cathormion umbellatum extracts against seven antibiotic-resistant bacteria. The pods, leaves and branches of C. umbellatum were extracted with ethanol and methanol. The disc diffusion assay was used to screen the antibacterial activity and broth microdilution and colorimetric assay were used to measure the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values. The result indicated that the highest inhibition zone (11 mm) was presented in ethanolic pods extract against multidrug resistance Klebsiella pneumoniae. The lowest MIC value of 0.05 mg/mL was obtained from branch extracted with ethanol against colistin resistant Pseudomonas aeruginosa. The lowest MBC values of 1.56 mg/mL were obtained when using C. umbellatum leaves extracted with methanol against all test antibiotic-resistant bacteria. This is the first report presented C. umbellatum extracts have the potential to eliminate antibiotic-resistant bacteria in patients. These findings show the antibacterial effect of C. umbellatum.
Abadi ATB, Rizvanov AA, Haertlé T, Blatt NL. World Health Organization report: Current crisis of antibiotic resistance. Bio Nano Sci. 2019; 9: 778-88.
Abdallah EM. Plants: An alternative source for antimicrobials. J Appl Pharm Sci. 2011; 1: 16-20.
Al-Harbi R, Al-wegaisi R, Moharram F, Shaaban M, Abd El-Rahman O. Antibacterial and anti-hemolytic activity of tannins from Pimenta dioica against methicillin resistant Staphylococcus aureus. Bangladesh J Pharmacol. 2017; 12: 63-68.
Bahmani M, Taherikalani M, Khaksarian M, Rafieian-Kopaei M, Ashrafi B, Nazer M, Soroush S, Abbasi N, Rashidipour M. The synergistic effect of hydroalcoholic extracts of Origanum vulgare, Hypericum perforatum and their active components carvacrol and hypericin against Staphylococcus aureus. Future Sci. 2019; 2019.
Bhattacharya PK. Emergence of antibiotic-resistant bacterial strains, methicillin-resistant Staphylococcus aureus, extended spectrum beta lactamases, and multi-drug resistance is a problem similar to global warming. Rev Soc Bras Med Trop. 2014; 47: 815-16.
Boongapim R, Ponyaim D, Phiwthong T, Rattanasuk S. In vitro antibacterial activity of Capparis sepiaria L. against human pathogenic Bacteria. Asian J Plant Sci. 2021; 20: 102-18.
Bugrysheva JV, Sue D, Gee JE, Elrod MG, Hoffmaster AR, Randall LB, Chirakul S, Tuanyok A, Schweizer HP, Weigel LM. Antibiotic resistance markers in Burkholderia pseudo-mallei strain Bp1651 identified by genome sequence analysis. Antimicrob Agents Chemother. 2017; 61: e00010-17.
Chiavari-Frederico MO, Barbosa LN, Carvalho dos Santos I, Ratti da Silva G, Fernandes de Castro A, de Campos Bortolucci W, Barboza LN, Campos CFdAA, Gonçalves JE, Menetrier JV. Antimicrobial activity of Asteraceae species against bacterial pathogens isolated from postmenopausal women. PLoS One. 2020; 15: e0227023.
Çıkman A, Parlak M, Bayram Y, Güdücüoğlu H, Berktaş M. Antibiotics resistance of Stenotrophomonas maltophilia strains isolated from various clinical specimens. Afr Health Sci. 2016; 16: 149-52.
de Moura PHB, de Sousa AA, Porzel A, Wessjohann LA, Leal ICR, Martins RCC. Characterization of antibacterial proanthocyanidins of dalbergia monetaria, an Amazonian medicinal plant, by UHPLC-HRMS/MS. Planta Med. 2020; 86: 858-66.
Dzotam JK, Touani FK, Kuete V. Antibacterial activities of the methanol extracts of Canarium schweinfurthii and four other Cameroonian dietary plants against multi-drug resistant Gram-negative bacteria. Saudi J Biol Sci. 2016; 23: 565-70.
Gregova G, Kmet V. Antibiotic resistance and virulence of Escherichia coli strains isolated from animal rendering plant. Sci Rep. 2020; 10: 1-7.
Habbal O, Hasson S, El-Hag A, Al-Mahrooqi Z, Al-Hashmi N, Al-Bimani Z, Al-Balushi M, Al-Jabri A. Antibacterial activity of Lawsonia inermis Linn (Henna) against Pseudomonas aeruginosa. Asian Pac J Trop Biomed. 2011; 1: 173-76.
Huai W, Ma Q-B, Zheng J-J, Zhao Y, Zhai Q-R. Distribution and drug resistance of pathogenic bacteria in emergency patients. World J Clin Cases. 2019; 7: 3175.
Karatuna O, Dance D, Matuschek E, Åhman J, Turner P, Hopkins J, Amornchai P, Wuthiekanun V, Cusack T-P, Baird R. Burkholderia pseudomallei multi-centre study to establish EUCAST MIC and zone diameter distributions and epidemiological cut-off values. Clin Microbiol Infect. 2021; 27: 736-41.
Kawamura-Sato K, Iinuma Y, Hasegawa T, Horii T, Yama-shino T, Ohta M. Effect of subinhibitory concentrations of macrolides on expression of flagellin in Pseudomonas aeruginosa and Proteus mirabilis. Antimicrob Agents Chemother. 2000; 44: 2869-72.
Khameneh B, Iranshahy M, Soheili V, Bazzaz BSF. Review on plant antimicrobials: A mechanistic viewpoint. Antimicrob Resist Infect Control. 2019; 2019.
Kidane A, Rezene A, G/Hannes O, G/Michael S, Mehreteab S, Jyoti SMJ, Andom H. Antibacterial activities of selected medicinal plants against multi-drug resistant bacteria isolated from urine samples of catheterized patients. Clin Microbiol. 2019; 2019.
Malaka M, Yanti N, Hartati R, Sahidin I. Radical scavenging and antibacterial activity of phenolic compounds from Anacardium occidentale L. stem barks from South East Sulawesi-Indonesia. Indian J Pharm Sci. 2018; 80: 143-49.
Miller WR, Munita JM, Arias CA. Mechanisms of antibiotic resistance in enterococci. Expert Rev Anti Infect Ther. 2014; 12: 1221-36.
Naeim H, El-Hawiet A, Rahman RAA, Hussein A, El Deme-llawy MA, Embaby AM. Antibacterial activity of Centaurea pumilio L. root and aerial part extracts against some multi-drug resistant bacteria. BMC Complement Med Ther. 2020; 20: 1-13.
Prestinaci F, Pezzotti P, Pantosti A. Antimicrobial resistance: A global multifaceted phenomenon. Pathog Glob Health. 2015; 109: 309-18.
Ramli S. Bioactivity evaluations and phytochemical characterizations of ethanolic extracts from selected mimosaceous plants endemic to Thailand. Chulalongkorn University. 2010.
Rattanasuk S, Phiwthong T. Evaluation of the antibacterial activity of Spathiphyllum wallisii extracts against human pathogenic bacteria. Pakistan J Biol Sci. 2020; 23: 1436-41.
Rattanasuk S, Phiwthong T. A New potential source of anti-pathogenic bacterial substances from Zamioculcas zamiifolia (Lodd.) Engl. extracts. Pakistan J Biol Sci. 2021; 24: 235-40.
Rauf A, Imran M, Abu-Izneid T, Iahtisham Ul H, Patel S, Pan X, Naz S, Sanches Silva A, Saeed F, Rasul Suleria HA. Pro-anthocyanidins: A comprehensive review. Biomed Pharmacother. 2019; 116: 108999.
Sadrati N, Zerroug A, Demirel R, Bakli S, Harzallah D. Anti-microbial activity of secondary metabolites produced by Aspergillus neobridgeri isolated from Pistacia lentiscus against multi-drug resistant bacteria. Bangladesh J Pharmacol. 2020; 15: 82-85.
Suttipalin S, Suttimas Y, Nirascha C. Effect of purified curcuminoids on Enterococcus faecalis and its biofilm. Int J Clin Prev Dent. 2014; 10:71-78.
Thamlikitkul V, Tiengrim S. In vitro activity of colistin plus sulbactam against extensive-drug-resistant Acinetobacter baumannii by checkerboard method. J Med Assoc Thai. 2014; 97: S1-S6.
Tumbarello M, Trecarichi EM, Fiori B, Losito AR, D'Inzeo T, Campana L, Ruggeri A, Di Meco E, Liberto E, Fadda G. Multidrug-resistant Proteus mirabilis bloodstream infections: Risk factors and outcomes. Antimicrob Agents Chemother. 2012; 56: 3224-31.
Tunsaringkarn T, Suwansaksri J, Rungsiyothin A, Palasuwan A. Cell proliferation activities in vitro model of Thai mimosaceous extracts. J Chem Pharm Res. 2014; 6: 507-11.
Wasihun AG, Kasa BG. Evaluation of antibacterial activity of honey against multidrug resistant bacteria in Ayder Referral and Teaching Hospital, Northern Ethiopia. Springer Plus. 2016; 5: 1-8.
Zhang Y, Wei J, Chen H, Song Z, Guo H, Yuan Y, Yue T. Antibacterial activity of essential oils against Stenotrophomonas maltophilia and the effect of citral on cell membrane. LWT. 2020; 117: 108667.
How to Cite
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).