Effect of Abutilon indicum in thyroxine-induced hyperthyroidism in rat

Authors

  • Qaiser Jabeen Department of Pharmacology, Faculty of Pharmacy, Islamia University of Bahawalpur, Bahawalpur, Pakistan. https://orcid.org/0000-0002-6346-860X
  • Muhammad Sohaib Khan Department of Pharmacology, Faculty of Pharmacy, Islamia University of Bahawalpur, Bahawalpur, Pakistan.
  • Abdul Wahid Qureshi Department of Pharmacology, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
  • Hafiz Muhammad Farhan Rasheed Department of Pharmacology, Faculty of Pharmacy, Islamia University of Bahawalpur, Bahawalpur, Pakistan. https://orcid.org/0000-0003-2516-7387

DOI:

https://doi.org/10.3329/bjp.v16i3.54174

Keywords:

Abutilon indicum , Hyperthyroidism, Thyroxine

Abstract

The study was designed to investigate the antithyroid activity of the crude methanolic (70%) extract of aerial parts of Abutilon indicum in male albino rats. The extract was prepared and analyzed for the presence of phytochemical constituents through preliminary chemical analysis, antioxidant assay and GC-MS. The in vivo antithyroid activities in thyroxine-induced hyperthyroidism were studied. Phytochemical analysis showed the presence of alkaloids, flavonoids and phenols, also verified by the data obtained from GC-MS. Thyroxine increased the levels of triiodothyronine (4.9 ± 0.1 ng/mL) and total thyroxine (9.4 ± 0.2 μg/dL); while, A. indicum at the doses of 300 and 500 mg/kg, showed significant decrease in the elevated levels of triiodothyronine (3.0 ± 0.1 and 2.6 ± 0.2 ng/mL) and thyroxine (7.7 ± 0.2 and 7.1 ± 0.2 μg/dL), respectively. Histopathological studies showed the restoration of filled follicular colloids in extract-treated animals. The results show that A. indicum exhibits dose-dependent antithyroid effects.

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Published

2021-08-08

How to Cite

Jabeen, Q., M. S. Khan, A. W. Qureshi, and H. M. F. Rasheed. “Effect of Abutilon Indicum in Thyroxine-Induced Hyperthyroidism in Rat”. Bangladesh Journal of Pharmacology, vol. 16, no. 3, Aug. 2021, pp. 103-1, doi:10.3329/bjp.v16i3.54174.

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Research Articles