Reintroduction of nitrofurantoin in the treatment of uncomplicated urinary tract infection

Authors

  • Sabiha Mahboob Department of Pharmacology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh.
  • Md. Sayedur Rahman Department of Pharmacology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh. http://orcid.org/0000-0002-5960-0161

DOI:

https://doi.org/10.3329/bjp.v16i3.54481

Keywords:

Nitrofurantoin, Uncomplicated urinary tract infection

Abstract

The present study was designed to reintroduce an older antimicrobial nitrofurantoin among a group of prescribers and to explore the relationship between the reintroduction and corresponding shift in sensitivity pattern of the microbes. The microbial sensitivity against ciprofloxacin before intervention was 46.6%, which significantly increased after intervention (51.8%). Treatment with nitrofurantoin resulted in a total clinical cure rate of 80.6%, of which rate of clinical cure achieved in expected time was 66.1% and delayed was 14.5%. The rate of total clinical cure with nitrofurantoin corresponded closely with the proportion of urinary isolates sensitive to nitrofurantoin. i.e., 86.3%. This preliminary study revealed that revival might be an effective strategy to increase the sensitivity and to delay the emergence of resistance.

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Author Biography

Md. Sayedur Rahman, Department of Pharmacology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh.

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Published

2021-07-03

How to Cite

Mahboob, S., and M. S. Rahman. “Reintroduction of Nitrofurantoin in the Treatment of Uncomplicated Urinary Tract Infection”. Bangladesh Journal of Pharmacology, vol. 16, no. 3, July 2021, pp. 87-90, doi:10.3329/bjp.v16i3.54481.

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Section

Research Articles