Hepatoprotective and anti-oxidant effect of Carissa spinarum root extract against CCl4 and paracetamol-induced hepatic damage in rats

Authors

  • Karunakar Hegde Department of Pharmacology, Srinivas College of Pharmacy Valachil, Post- Parangepete, Mangalore, Karnataka
  • Arun B. Joshi Department of Pharmacognosy, Goa College of Pharmacy, Panaji, Goa

DOI:

https://doi.org/10.3329/bjp.v5i1.5681

Keywords:

Carissa spinarum, Hepatoprotection, Oxidative stress

Abstract

Ethanolic extract of the roots of C. spinarum was evaluated for hepatoprotective and anti-oxidant activities in rats. Oral pre-treatment with ethanolic extract (100, 200 and 400 mg/kg) showed significant hepatoprotective activity against CCl4 and paracetamol-induced hepatotoxicity by decreasing the activities of bilirubin and lipid peroxidation, and significant increase in the levels of uric acid, glutathione, super oxide dismutase, catalase and protein in a dose dependent manner, which was confirmed by the decrease in liver wet weight and histopathological examination. The extract possessed strong anti-oxidant activity. This suggests that the hepatoprotective activity of C. spinarum is possibly attributed to its free radical scavenging properties.

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Published

2010-10-14

How to Cite

Hegde, K., and A. B. Joshi. “Hepatoprotective and Anti-Oxidant Effect of Carissa Spinarum Root Extract Against CCl4 and Paracetamol-Induced Hepatic Damage in Rats”. Bangladesh Journal of Pharmacology, vol. 5, no. 1, Oct. 2010, pp. 73-76, doi:10.3329/bjp.v5i1.5681.

Issue

Vol. 5 No. 1 (2010)

Section

Research Articles

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