Sesquiterpene compound α-cyperone relieves the injury in neurons undergoing oxygen-glucose deprivation/reoxygenation

Authors

  • Jian Wang Department of Neurology, Chengdu Eighth People’s Hospital (Geriatric Hospital of Chengdu Medical College), Chengdu, Sichuan, 610083 China.
  • Xuefeng Gao School of Management, Capital Normal University, Beijing 100089, China.

DOI:

https://doi.org/10.3329/bjp.v17i2.58188

Keywords:

AK-7, alpha-cyperone, Neuron, oxygen-glucose deprivation/reoxygenation, Sirtuin 2, Western blot

Abstract

The present study aimed to explore the effects of α-cyperone, an extract of Cyperus rotundus, on PC12 cells, as well as the underlying mechanism. Following the cells were induced by oxygen-glucose deprivation/reoxygena-tion (OGD/R), the viability, morphology, inflammation, oxidative stress and apoptotic levels in the cells were evaluated. To explore the mechanism of α-cyperone, cells were treated with 3-TYP, a sirtuin-3 (SIRT3) inhibitor, and then the effects of 3-TYP on the function of α-cyperone were assessed. α-Cyperone was found to reduce OGD/R-induced damage to neuronal viability and alleviate inflammation, oxidative stress, and apoptosis. In addition, α-cyperone could elevate SIRT3 and decline acetyl-forkhead box O1 (FOXO1) levels, and 3-TYP broke the effects of α-cyperone on the aforementioned aspects in the PC12 cells. In conclusion, α-cyperone activated SIRT3 and FOXO1 deacetylation, and alleviated OGD/R-induced cell inflammation, oxidative stress, and apoptosis.

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References

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Published

2022-06-06

How to Cite

Wang, J., and X. Gao. “Sesquiterpene Compound α-Cyperone Relieves the Injury in Neurons Undergoing Oxygen-Glucose deprivation/Reoxygenation”. Bangladesh Journal of Pharmacology, vol. 17, no. 2, June 2022, pp. 23-31, doi:10.3329/bjp.v17i2.58188.

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Research Articles