Antianxiety and antidepressant effects of aqueous latex extract of Euphorbia resinifera

Authors

  • Majda Badaoui Laboratory of Pharmacology, Neurobiology, Anthropology and Environment, Department of Biology, Faculty of Sciences, Semlalia, University Cadi Ayyad, BP 2390-40080 Marrakech, Morocco.
  • Soad Moubtakir Laboratory of Pharmacology, Neurobiology, Anthropology and Environment, Department of Biology, Faculty of Sciences, Semlalia, University Cadi Ayyad, BP 2390-40080 Marrakech, Morocco. https://orcid.org/0000-0002-2317-2839
  • Chafik Terrafe Laboratory of Pharmacology, Neurobiology, Anthropology and Environment, Department of Biology, Faculty of Sciences, Semlalia, University Cadi Ayyad, BP 2390-40080 Marrakech, Morocco. https://orcid.org/0000-0001-6827-6482
  • Rachida Aboufatima Laboratory of Genie Biologic, Sultan Moulay Slimane University, Faculty of Sciences and Technics, Beni Mellal, Moroocco. https://orcid.org/0000-0002-6021-3230
  • Abderrahman Chait Laboratory of Pharmacology, Neurobiology, Anthropology and Environment, Department of Biology, Faculty of Sciences, Semlalia, University Cadi Ayyad, BP 2390-40080 Marrakech, Morocco. https://orcid.org/0000-0002-5639-1931

DOI:

https://doi.org/10.3329/bjp.v17i2.59258

Keywords:

Antidepressant, Anxiolytic, Antioxidant, Elevated plus maze test, Euphorbia re

Abstract

This study aims to examine the antianxiety and antidepressant effects of aqueous latex extract of Euphorbia resinifera in mice. Antianxiety and sedative effects were examined using the elevated plus maze test, open field test, and thiopental-induced sleeping time respectively. While the antidepressant effect was evaluated, using the forced swimming test. E. resinifera reduced the latency of sleeping and increased sleeping time significantly at 75 mg/kg. It reduced the immobility time and increased swimming significantly at all doses assessed (25, 50, and 75 mg/kg). Pretreatment with antagonists reversed these effects indicating the possible involvement of α2, 5HT2, D2, and GABAA receptors respectively. These findings confirm the traditional utilization of this plant as an antioxidant, anxiolytic, and antidepressant.

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Author Biography

Abderrahman Chait, Laboratory of Pharmacology, Neurobiology, Anthropology and Environment, Department of Biology, Faculty of Sciences, Semlalia, University Cadi Ayyad, BP 2390-40080 Marrakech, Morocco.

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Published

2022-06-06

How to Cite

Badaoui, M., S. Moubtakir, C. Terrafe, R. Aboufatima, and A. Chait. “Antianxiety and Antidepressant Effects of Aqueous Latex Extract of Euphorbia Resinifera”. Bangladesh Journal of Pharmacology, vol. 17, no. 2, June 2022, pp. 32-41, doi:10.3329/bjp.v17i2.59258.

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Research Articles