Antianxiety and antidepressant effects of aqueous latex extract of Euphorbia resinifera
DOI:
https://doi.org/10.3329/bjp.v17i2.59258Keywords:
Antidepressant, Anxiolytic, Antioxidant, Elevated plus maze test, Euphorbia reAbstract
This study aims to examine the antianxiety and antidepressant effects of aqueous latex extract of Euphorbia resinifera in mice. Antianxiety and sedative effects were examined using the elevated plus maze test, open field test, and thiopental-induced sleeping time respectively. While the antidepressant effect was evaluated, using the forced swimming test. E. resinifera reduced the latency of sleeping and increased sleeping time significantly at 75 mg/kg. It reduced the immobility time and increased swimming significantly at all doses assessed (25, 50, and 75 mg/kg). Pretreatment with antagonists reversed these effects indicating the possible involvement of α2, 5HT2, D2, and GABAA receptors respectively. These findings confirm the traditional utilization of this plant as an antioxidant, anxiolytic, and antidepressant.
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Abbasi-Maleki S, Bakhtiarian A, Nikoui V. Involvement of the monoaminergic system in the antidepressant-like effect of the crude extract of Menthapiperita (Lamiaceae) in the forced swimming test in mice. Synergy 2017; 5: 21-28.
Adeneye AA, Ajagbonna OP, Adeleke TI, Bello SO. Preliminary toxicity and phytochemical studies of the stem bark aqueous extract of Musanga cecropioides in rats. J Ethnopharmacol. 2006; 105: 374-79.
Anuradha H, Srikumar BN, Rao BSS, Lakshmana M. Euphorbia hirta reverses chronic stress-induced anxiety and mediates its action through the GABA A receptor benzodiazepine receptor-Cl− channel complex. J Neural Transm. 2008; 115: 35-42.
Appendino G, Szallasi A. Euphorbium: Modern research on its active principle, resiniferatoxin, revives an ancient medicine. Life Sci. 1997; 60: 681-96.
Benharref A, Lavergne JP. Triterpènes issus des latex des euphorbes cactoides marocaines E. resinifera, E. echinus et E. officinarum: Isolement, étude comparative par RMN 13C des quatre classes tétracycliques, eupho-lanostane, élémo-lanostane, lanostane etnor-31 lanostane. Bull Soc Chim. 1985; 5: 965-72.
Brighente IMC, Dias M, Verdi LG, Pizzolatti MG. Antioxidant activity and total phenolic content of some Brazilian species. Pharm Biol. 2007; 45: 156-61.
Brown R.E, Corey S.C, Moore A.K. Differences in measures of exploration and fear in MHC-congenic C57BL/6J and B6-H-2K mice. Behav Genet. 1999; 29: 263-71.
Costa JP, de Oliveira GA, de Almeida AA, Islam MT, de Sousa DP, de Freitas RM. Anxiolytic-like effects of phytol: Possible involvement of GABAergic transmission. Brain Res. 2014; 1547: 34-42.
da Silva Almeida JR, de Souza AV, de Oliveira AP, dos Santos US, de Souza MD, dos Passos Bispo L, Turatti IC, Lopes NP. Chemical composition of essential oils from the stem barks of Croton conduplicatus (Euphorbiaceae) native to the Caatinga biome. Afr J Pharm Pharmacol. 2015; 9: 98-101.
Detke M.J, Rickels M, Lucki I. Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology 1995; 121: 66-72.
Dhingra D, Sharma A. Antidepressant-like activity of Glycyrrhiza glabra L. in mouse models of immobility tests. Prog Neuro-Psychopharmacol Biol Psychiatry. 2006; 30: 449-54.
El Gabbas Z, Bezza K, Laadraoui J, Makbal R, Aboufatima R, Chait A. Salvia officinalis induces antidepressant-like effect, anxiolytic activity and learning improvement in hippocampal lesioned and intact adult rats. Bangladesh J Pharmacol. 2018; 13: 367-78.
Fellegrini N, Ke R, Yang M, Rice-Evans C. Screening of dietary carotenoids and carotenoid-rich fruit extracts for antioxidant activities applying 2, 2′-azinobis (3-ethylenebenzothiazoline-6-sulfonic acid radical cation decolorization assay. Meth Enzymol. 1999; 299: 379-89.
Foyet SH, Balmus IM, Hervé NAH, Emmanuel AA, Guenne S, Kiendrebéogo M, Ciobica A. Ethnopharmacological approaches in mood and anxiety disorders: The relevance of the oxidative stress status. J Complement Integr Med. 2017; 2017.
Frazer A. Norepinephrine involvement in antidepressant action. J Clin Psychiatry. 2000; 61: 25-30.
Gu L, Liu YJ, Wang YB, Yi LT. Role for monoaminergic systems in the antidepressant-like effect of ethanol extracts from Hemerocallis citrina. J Ethnopharmacol. 2012; 139: 780-87.
Haq IU, Aslam M, Ahmed H, Sultana N. Antidepressant-like activity of hydroalcoholic extract of Agaricus blazei in stressed and unstressed mice. Bangladesh J Pharmacol. 2019; 14: 136-43.
Kaur J, Bhatia M, Nain P. Antidepressant activity of Citrus limetta leaves in mice using battery of behavior models modulating via serotonergic systems. Bangladesh J Pharmacol. 2019; 14: 181-87.
Komada M, Takao K, Miyakawa T. Elevated plus maze for mice. JoVE. 2008: 2008.
Jawad M, Khan H, Pervaiz S, Bawazeer SS, Abu-Izneid T, Saeed M, Kamal MA. Pharmacological validation of the anxiolytic, muscle relaxant and sedative like activities of Capsicum annuum in animal model. Bangladesh J Pharmacol. 2017; 12: 439-47.
Khanzode S.D, Dakhale G.N, Khanzode S.S, Saoji A, Palasod-kar R. Oxidative damage and major depression: The potential antioxidant action of selective serotonin re-uptake inhibitors. Redox Report. 2003; 8: 365-70.
Lambert G, Johansson M, Ågren H, Friberg P. Reduced brain norepinephrine and dopamine release in treatment-refractory depressive illness: Evidence in support of the catechola-mine hypothesis of mood disorders. Arch Gen Psychiatry. 2000; 57: 787-93.
Lanhers MC, Fleurentin J, Cabalion P, Rolland A, Dorfman P, Misslin R, Pelt JM. Behavioral effects of Euphorbia hirta L.: Sedative and anxiolytic properties. J Ethnopharmacol. 1990; 29: 189-98.
Licá ICL, dos Santos Soares AM, de Mesquita LSS, Malik S. Biological properties and pharmacological potential of plant exudates. Food Res Int. 2018; 105: 1039-53.
Majid M, Khan M.R, Shah N.A, Haq I.U, Farooq M.A, Ullah S, Sharif A, Zahra Z, Younis T, Sajid M. Studies on phytochemical, antioxidant, anti-inflammatory and analgesic activities of Euphorbia dracunculoides. BMC Complement Alternat Med. 2015; 15: 1-15.
Masuda Y, Ohnuma S, Sugiyama T. Mouse forced swimming. Methods Find Exp Clin Pharmacol. 2001; 23: 19-21.
Maqbool S, Younus I. Anxiolytic and hypnotic effects of Cocculus laurifolius leaf extract in mice. Bangladesh J Pharmacol. 2019; 14: 45-53.
Nicoletta F, Roberta R, Min Y, Catherine RE. Screening of dietary carotenoids and carotenoid-rich fruit extracts for antioxidant activities applying 2, 2′-azinobis (3-ethylenebenzothiazoline-6-sulfonic acid radical cation decolorization assay. Meth Enzymol. 1999; 299: 379-89.
Nutt DJ. Relationship of neurotransmitters to the symptoms of major depressive disorder. J Clin Psychiatry. 2008; 69: 4-7.
Oketch-Rabah HA. Mondia whitei, a medicinal plant from Africa with aphrodisiac and antidepressant properties: A review. J Diet Suppl. 2012; 9: 272-84.
Oyaizu M. Studies on products of browning reaction anti-oxidative activities of products of browning reaction prepared from glucosamine. Japanese J Nutr Diet. 1986; 44: 307-15.
Pandey SC, Ren X, Sagen J, Pandey GN. β-Adrenergic receptor subtypes in stress-induced behavioral depression. Pharmacol Biochem Behav. 1995; 51: 339-44.
Patchev VK, Patchev AV. Experimental models of stress. Dialogues Clin Neurosci. 2006; 8: 417.
Pintus F, Spanò D, Mascia C, Macone A, Floris G, Medda R. Acetylcholinesterase inhibitory and antioxidant properties of Euphorbia characias latex. Rec Nat Prod. 2013; 7, 147-51.
Price M.L, van Scoyoc S, Butler L.G. A critical evaluation of the vanillin reaction as an assay for tannin in sorghum grain. J Agric Food Chem. 1978; 26: 1214-18.
Pytka K, Podkowa K, Rapacz A, Podkowa A, Żmudzka E, Olczyk A, Sapa J, Filipek B. The role of serotonergic, adrenergic and dopaminergic receptors in antidepressant-like effect. Pharmacol Rep. 2016; 68: 263-74.
Sahin F, Güllüce M, Daferera D, Sökmen A, Sökmen M, Polissiou M, Agar G, Özer H. Biological activities of the essential oils and methanol extract of Origanum vulgare ssp. vulgare in the Eastern Anatolia region of Turkey. Food Control. 2004; 15: 549-57.
Singleton VL, Orthofer R, Lamuela-Ravent6s RM. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Meth Enzymol. 1999; 299: 152-78.
Siritapetawee J, Khunkaewla P, Thumanu K. Roles of a pro-tease from Euphorbia resinifera latex in human anticoagulant and antithrombotic activities. Chem Biol Interact. 2020; 329: 109223.
Stewart SA. The effects of benzodiazepines on cognition. J Clin Psychiatry. 2005; 66: 9-13.
Tian J, Zhang F, Cheng J, Guo S, Liu P, Wang H. Antidepressant-like activity of adhyperforin, a novel constituent of Hypericum perforatum L. Sci Rep. 2014; 4: 1-6.
Wu MX, Ma XJ, Shi JL, Wang SN, Zheng ZQ, Guo JY. Acute and subacute oral toxicity studies of the aqueous extract from radix, radix with cortex and cortex of Psammosilene tunicoides in mice and rats. J Ethnopharmacol. 2018; 213: 199-209.
Xiao-Yang WA, Li-Ping LI, Ting-Guo KA, Hong-Bing WA. Chemical constituents of Euphorbia fischeriana. Chinese J Nat Med. 2012; 10: 299-302.
Xu Y, Wang C, Klabnik JJ, O’donnell JM. Novel therapeutic targets in depression and anxiety: Antioxidants as a candidate treatment. Curr Neuropharmacol. 2014; 12: 108-19.
Yamada J, Sugimoto Y, Yamada S. Involvement of dopamine receptors in the anti-immobility effects of dopamine re-uptake inhibitors in the forced swimming test. Eur J Pharmacol. 2004; 504: 207-11.
Zhao ND, Li YL, Song Y, Yang BJ, Ding X, Gao F, Ye J, Hao XJ, Zhang Y, Li S. Ten new nortriterpenes from Euphorbia resinifera and their anti-tomato yellow leaf curl virus activities. Fitoterapia 2021; 153: 104989.
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Copyright (c) 2022 Majda Badaoui, Soad Moubtakir, Chafik Terrafe, Rachida Aboufatima, Abderrahman Chait
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