Anti-diabetic activity of Allium wallichii on streptozotocin-nicotinamide-induced type-2 diabetes in rat
DOI:
https://doi.org/10.3329/bjp.v17i4.62273Keywords:
Allium wallichii, Anti-diabetic, InsulinAbstract
The aim of the present study was to investigate the effect of Allium wallichii leaves extract against streptozotocin-nicotinamide-induced type-2 diabetes in rats. The hydroalcohol extract of A. wallichii leaves (200 and 400 mg/kg) was tested for oral glucose tolerance test and in non-insulin-dependent diabetes mellitus-induced elevated serum glucose levels in the rat. Interestingly, single oral administration of A. wallichii caused a significant (p<0.05) reduction in the serum glucose level (mg/dL). On other hand, A. wallichii normalized plasma glucose levels after repeated oral administration for up to 21 days in diabetic rats (p<0.05). The A. wallichii in the dose of 400 mg/kg showed significant effects on streptozotocin-nicotinamide-induced type-2 non-insulin-dependent diabetes mellitus in rats. In conclusion, therapeutic potential of A. wallichii as per claims is validated towards anti-diabetic potential.
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Acharya K, Pokhrel H, Maharjan L, Bhattarai R, Karki P, Shrestha TM, Gyawali R. Comparative study of antibacterial and cytotoxic activity of two Nepalese medicinal plants: Allium wallichii Kunth and Allium sativum L. Int J Pharm Biol Sci Arch. 2011; 2: 1539-43.
Agrawal R, Sethiya NK, Mishra SH. Antidiabetic activity of alkaloids of Aerva lanata roots on streptozotocin-nicotinamide induced type-II diabetes in rats. Pharm Biol. 2013; 51: 635-42.
Akash MSH, Rehman K, Chen S. Spice plant Allium cepa: Dietary supplement for treatment of type 2 diabetes mellitus. Nutrition 2014; 30: 1128-37.
Balamash KS, Alkreathy HM, Gahdali EHA, Khoja SO, Ahmad A. Comparative biochemical and histopathological studies on the efficacy of metformin and virgin olive oil against streptozotocin-induced diabetes in Sprague-Dawley rats. J Diabetes Res. 2018; 2018: 4692197.
Baskaran K, Ahamath BK, Shanmugasundaram KR, Shanmugasundaram ER. Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes melli-tus patients. J Ethnopharmacol. 1990; 30: 295-300.
Bhandari J, Muhammad BT, Thapa P, Shrestha BG. Study of phytochemical, anti-microbial, antioxidant, and anti-cancer properties of Allium wallichii. BMC Complement Altern Med. 2017; 17: 102.
Bhatt D, Sethiya NK, Mishra SH. Pharmacognostic studies on the aerial parts of Suaeda maritima Linn. (Chenopodiaceae). Niger J Nat Prod Med. 2010; 14: 1-5.
Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L. juice II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomedicine 1996; 3: 245-48.
Chatterjee S, Khunti K, Davies MJ. Type 2 diabetes. Lancet 2017; 389: 2239-51.
Damasceno DC, Netto AO, Iessi IL, Gallego FQ, Corvino SB, Dallaqua B, Sinzato YK, Bueno A, Calderon IMP, Rudge MVC. Streptozotocin-induced diabetes models: Pathophysiological mechanisms and fetal outcomes. Biomed Res Int. 2014; 2014: 819065.
Eidi A, Eidi M, Esmaeili E. Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocin-induced diabetic rats. Phytomedicine 2006; 13: 624-29.
Fazelipour S, Jahromy MH, Tootian Z, Goodarzi N. Anti-diabetic effects of the ethanolic extract of Allium saralicum R.M. Fritsch on streptozotocin‐induced diabetes in a mice model. Food Sci Nutr. 2021; 9: 4815-26.
Geberemeskel GA, Debebe YG, Nguse NA. Antidiabetic Effect of fenugreek seed powder solution (Trigonella foenum-graecum L.) on hyperlipidemia in diabetic patients. J Diabetes Res. 2019; 2019: 8507453.
Iqbal J, Abbasi BA, Batool R, Mahmood T, Ali B, Khalil AT, Kanwal S, Shah SA, Ahmad R. Potential phytocompounds for developing breast cancer therapeutics: Nature’s healing touch. Eur J Pharmacol. 2018; 827: 125-48.
Irondi EA, Oboh G, Akindahunsi AA. Antidiabetic effects of Mangifera indica kernel flour‐supplemented diet in streptozotocin‐induced type 2 diabetes in rats. Food Sci Nutr. 2016; 4: 828-39.
Joseph B, Jini D. Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency. Asian Pac J Trop Dis 2013; 3: 93-102.
Kamal R, Sharma GL. Steroidal sapogenins from bulbs of Allium wallichii Kunth. Pharmazie 1984; 39: 707-08.
Kattel A, Maga JA. Volatile compounds from dried Jimbu (Allium wallichii). Dev Food Sci.1995; 37: 919-28.
Khan MAB, Hashim MJ, King JK, Govender RD, Mustafa H, Kaabi JA. Epidemiology of type 2 diabetes: Global burden of disease and forecasted trends. J Epidemiol Glob Health. 2020; 10: 107-11.
Kim S, Jo S, Kwon Y, Hwang J. Effects of onion (Allium cepa L.) extract administration on intestinal α-glucosidases activities and spikes in postprandial blood glucose levels in SD rats model. Int J Mol Sci. 2011; 12: 3757-69.
Melino S, Leo S, Papajani VT. Natural hydrogen sulfide donors from Allium sp. as a nutraceutical approach in type 2 diabetes prevention and therapy. Nutrients 2019; 11: 1581.
Perumal N, Nallappan M, Shohaimi S, Kassim NK, Tee TT, Cheah YH. Synergistic antidiabetic activity of Taraxacum officinale (L.) Weber ex F.H. Wigg and Momordica charantia L. polyherbal combination. Biomed Pharmacother. 2022; 145: 112401.
Raghav SS, Kumar B, Sethiya NK, Kaul A. A Mechanistic insight on phytoconstituents delivering hypoglycemic activity: A comprehensive overview. Future Pharmacol. 2022; 2: 511-46.
Rana VS, Bisht D, Chaudhary SK, Gupta R, Sethiya NK. Stomatal analysis of Allium wallichii Kunth leaves: An experimental finding through quantitative microscopy. J Nat Remedies. 2022a; 22: 1-6.
Rana VS, Sethiya NK, Duseja M, Gupta R, Bisht D, Gangal A. Ethnomedicinal and traditional application of Allium wallichii Kunth (Himalayan onion): An unexplored and underutilized nutraceutical plant foods from Himalayan regions. Ethnobot Res Appl. 2022b; 24: 1-16.
Sabu MC, Kuttan R. Antidiabetic activity of Aegle marmelos and its relationship with its antioxidant properties. Indian J Physiol Pharmacol. 2004; 48: 81-88.
Satyanarayana K, Sravanthi K, Anand Shaker I, Ponnulakshmi R. Molecular approach to identify antidiabetic potential of Azadirachta indica. J Ayurveda Integr Med. 2015; 6: 165-74.
Sharma R, Amin H, Galib, Prajapati PK. Antidiabetic claims of Tinospora cordifolia (Willd.) Miers: Critical appraisal and role in therapy. Asian Pac J Trop Biomed. 2015; 5: 68-78.
Sørnes E, Risal A, Manandhar K, Thomas H, Steiner TJ, Linde M. Use of medicinal plants for headache, and their potential implication in medication-overuse headache: Evidence from a population-based study in Nepal. Cephalalgia 2021; 41: 561-81.
Thomson M, Al-Qattan KK, JS D, Ali M. Anti-diabetic and antioxidant potential of aged garlic extract (AGE) in streptozotocin-induced diabetic rats. BMC Complement Altern Med. 2015; 16: 17.
Tsai CY, Wen SY, Shibu MA, Yang YC, Peng H, Wang B, Wei YM, Chang HY, Lee CY, Huang CY, Kuo WW. Diallyl tri-sulfide protects against high glucose-induced cardiac apoptosis by stimulating the production of cystathionine gamma-lyase-derived hydrogen sulfide. Int J Cardio. 2015; 195: 300-10.
Venkatesh S, Thilagavathi J, Sundar DS. Anti-diabetic activity of flowers of Hibiscus rosasinensis. Fitoterapia 2008; 79: 79-81.
Wan Q, Li N, Du L, Zhao R, Yi M, Xu Q, Zhou Y. Allium vegetable consumption and health: An umbrella review of meta‐analyses of multiple health outcomes. Food Sci Nutr. 2019; 7: 2451-70.
Wang F, Xu Y, Liu P, Li L, Liu Y. The effects of alcohol and water extracts of Allium wallichii Kunth on transplanted hepatoma, lung cancer and breast cancer of mice. Med Plant. 2016; 7: 56-59.
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