Anticataract activity of Erythrina stricta against naphthalene-induced cataractogenesis in rats

Authors

  • Muthuswamy Umamaheswari Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore 641 044, Tamil Nadu
  • Kuppuswamy Asokkumar Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore 641 044, Tamil Nadu
  • Thirumalaiswamy Sivashanmugam Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore 641 044, Tamil Nadu
  • Varadharajan Subhadradevi Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore 641 044, Tamil Nadu
  • Michael Neethu Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore 641 044, Tamil Nadu

DOI:

https://doi.org/10.3329/bjp.v5i2.6582

Keywords:

antioxidant activity, cataract, Erythrina stricta, lipid peroxidation, naphthalene, opacity index

Abstract

The anticataract activity of Erythrina stricta leaves against naphthalene-induced cataractogenesis was studied in Wistar albino rats. The various fractions of the leaf extract were administered orally (200 mg/kg) simultaneously with naphthalene (1 g/kg) for 28 days. At the end of the experiment, levels of malondialdehyde, lipid hydroperoxides, carbonyl and sulfhydryl content, enzymatic and non-enzymatic antioxidants in lens homogenate were measured. Administration of naphthalene produced a mature cataract and an increase in the opacity index. There was a significant increase in lipid peroxidation and a decrease in antioxidant enzymes when compared to normal control. Ophthalmoscopic observation indicated that simultaneous administration of the fractions delayed the onset and maturation of cataract. All the fractions (except the residual fraction) prevented the peroxidative damage caused by naphthalene. The leaves of E. stricta protected the lens against naphthalene damage which may be due to its anti-oxidant activity.

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Author Biography

Muthuswamy Umamaheswari, Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore 641 044, Tamil Nadu

Assistant Professor

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Published

2010-12-27

How to Cite

Umamaheswari, M., K. Asokkumar, T. Sivashanmugam, V. Subhadradevi, and M. Neethu. “Anticataract Activity of Erythrina Stricta Against Naphthalene-Induced Cataractogenesis in Rats”. Bangladesh Journal of Pharmacology, vol. 5, no. 2, Dec. 2010, pp. 77-81, doi:10.3329/bjp.v5i2.6582.

Issue

Vol. 5 No. 2 (2010)

Section

Research Articles

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