Vigna mungo possesses pharmacological potential for the management of hyperthyroidism and improves estrus cycle disturbances
DOI:
https://doi.org/10.3329/bjp.v18i3.65860Keywords:
ELISA, Estrus cycle disturbance, Hyperthyroidism, Thyroxine, Triiodothyronine, TSH, Vigna mungoAbstract
The study was designed to investigate the pharmacological potential of 70%methanolic extract of Vigna mungo for the management of hyperthyroidism and estrus cycle disturbances in female rats. The preliminary phytochemical analysis of the extract was performed. Hyperthyroidism was induced by administering levothyroxine (600 µg/kg; orally) for 14 days. Phytochemical analysis of the extract showed the presence of alkaloids, flavonoids, phenols, saponins, fats, and oils. The extract (300, 500, and 1,000 mg/kg; orally) and carbimazole (30 mg/kg; orally) were administered individually for the next 14 days. The extract showed dose-dependent antithyroid potential, as evidenced by the decrease in T3 and T4, and the increase in TSH levels. Body weight, body temperature, fasting blood glucose levels, and prolonged diestrus phase were reversed towards normal and significant effects on the morphology of the thyroid gland and ovary of the rats were observed. Therefore, the findings reveal that V. mungo has the potential to treat experimentally-induced hyperthyroidism and estrus cycle disturbances.
Downloads
5
2
References
Akram A, Jamshed A, Anwaar M, Rasheed HMF, Haider SI, Aslam N, Jabeen Q. Evaluation of Caralluma edulis for its potential against obesity, atherosclerosis and hypertension. Dose-Response. 2023; 21: 1-12.
Armanini D, Castello R, Scaroni C, Bonanni G, Faccini G, Pellati D, Bertoldo A, Fiore C, Moghetti P. Treatment of polycystic ovary syndrome with spironolactone plus licorice. Eur J Obstet Gynecol Reprod Biol. 2007; 131: 61-67.
Audu SA, Mohammed I, Kaita HA. Phytochemical screening of the leaves of Lophira lanceolata (Ochanaceae). Life Sci J. 2007; 4: 75-79.
Bajaj JK, Salwan P, Salwan S. Various possible toxicants involved in thyroid dysfunction: A review. J Clin Diagn Res. 2016; 10: FE01-03.
Banik B, Das S, Das MK. Medicinal plants with potent anti-inflammatory and anti-arthritic properties found in eastern parts of the Himalaya: An ethnomedicinal review. Pharma-cogn Rev. 2021; 14: 121-37.
Chan CC, Koo MW, Ng EH, Tang OS, Yeung WS, Ho PC. Effects of Chinese green tea on weight, and hormonal and biochemical profiles in obese patients with polycystic ovary syndrome: A randomized placebo-controlled trial. J Soc Gynecol Investig. 2006; 13: 63-68.
Chinedu E, Arome D, Ameh FS. A new method for determining acute toxicity in animal models. Toxicol Int. 2013; 20: 224-26.
Cora MC, Kooistra L, Travlos G. Vaginal cytology of the laboratory rat and mouse: Review and criteria for the staging of the estrous cycle using stained vaginal smears. Toxicol Pathol. 2015; 43: 776-93.
Demirel MA, Ilhan M, Suntar I, Keles H, Akkol EK. Activity of Corylus avellana seed oil in letrozole-induced polycystic ovary syndrome model in rats. Rev Bras Farmacogn. 2016; 26: 83-88.
Elbandrawy M, Taha A, Tousson E, Hassan N. Different stages of hyperthyroidism: Alterations in proliferation, apoptosis, and histology of female rat ovary. Res J Pharm Biol Chem Sci. 2018; 9: 1458-71.
Evans RW, Chen TJ, Hendry WJ, Leavitt WW. Progesterone regulation of estrogen receptor in the hamster uterus during the estrous cycle. Endocrinology 1980; 107: 383-90.
Fasciolo G, Napolitano G, Aprile M, Cataldi S, Costa V, Muscari Tomajoli MT, Lombardi A, Di Meo S, Venditti P. Muscle oxidative stress plays a role in hyperthyroidism-linked insulin resistance. Antioxidants 2023; 12: 592.
Ghasemzadeh A, Farzadi L, Khaki A, Khan Ahmadi S. Effect of Allium cepa seeds ethanolic extract on experimental polycystic ovary syndrome (PCOS) apoptosis induced by estradiol-valerate. Life Sci J. 2013; 10: 170-75.
Gilani AH, Jabeen Q, Khan AU, Shah AJ. Gut modulatory, blood pressure lowering, diuretic and sedative activities of cardamom. J Ethnopharmacol. 2008; 115: 463-72.
Hassan AA, Ali MM. Effect of combined carbimazole and Curcuma longa powder in human thyroid-stimulating hormone and thyroperoxidase antibody in hyperthyroidism. Int J Pharmacol Pharm Sci. 2021; 15: 80-87.
Jabeen Q, Khan MS, Qureshi AW, Rasheed HMF. Effect of Abutilon indicum in thyroxine-induced hyperthyroidism in rat. Bangladesh J Pharmacol. 2021; 16: 103-113.
Jadhav M, Menon S, Shailajan S. Anti-androgenic effect of Symplocos racemosa Roxb. against letrozole induced polycystic ovary using rat model. J Coast Life Med. 2013; 1: 309-14.
Jana S, Shekhawat GS. Phytochemical analysis and antibacterial screening of in vivo and in vitro extracts of Indian medicinal herb: Anethum graveolens. Res J Med Plant. 2010; 4: 206-12.
Kar A, Panda S, Bharti S. Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. J Ethnopharmacol. 2002; 81: 281-85.
Li VVA, Baloch ZW. The pathology of hyperthyroidism. Front Endocrinol. 2018; 9: 737-37.
Maes M, Mommen K, Hendrickx D, Peeters D, D’Hondt P, Ranjan R, De Meyer F, Scharpe S. Components of biological variation, including seasonality, in blood concentrations of TSH, TT3, FT4, PRL, cortisol and testosterone in healthy volunteers. Clin Endocrinol. 1997; 46: 587-98.
Mandal S, Patra A, Samanta A, Roy S, Mandal A, Mahapatra TD, Pradhan S, Das K, Nandi DK. Analysis of phytochemical profile of Terminalia arjuna bark extract with antioxidative and antimicrobial properties. Asian Pac J Trop Biomed. 2013; 3: 960-66.
Marka R, Talari S, Penchala S, Rudroju S, Swamy Nanna R. Preliminary phytochemical analysis of leaf, stem, root and seed extracts of Arachis hypogaea L. Int J Pharm Sci Rev Res. 2013; 20: 134-39.
Mitrou P, Boutati E, Lambadiari V, Tsegka A, Raptis AE, Toun-tas N, Economopoulos T, Raptis SA, Dimitriadis G. Insulin resistance in hyperthyroidism: The role of IL6 and TNFα. Eur J Endocrinol. 2010; 162: 121-26.
Oshima M, Gu Y, Tsukada S. Effects of Lepidium meyenii Walp and Jatropha macrantha on blood levels of estradiol-17β, progesterone, testosterone and the rate of embryo implantation in mice. J Vet Med Sci. 2003; 65: 1145-46.
Radha M, Padamnabhi N, Laxmipriya N. Evaluation of Aloe barbadensis mill. Gel on letrozole induced polycystic ovarian syndrome (pcos) rat model: A dose dependent study. Int J Pharm Sci Res. 2014; 5: 5293-300.
Reddy PS, Begum N, Mutha S, Bakshi V. Beneficial effect of curcumin in letrozole induced polycystic ovary syndrome. Asian Pac J Reprod. 2016; 5: 116-22.
Rooney S, Pendry B. Phytotherapy for polycystic ovarian syndrome: A review of the literature and evaluation of practitioners’ experiences. J Herb Med. 2014; 4: 159-71.
Shah SA, Akhtar N, Akram M, Shah PA, Saeed T, Ahmed K, Asif H. Pharmacological activity of Althaea officinalis L. J Med Plant Res. 2011; 5: 5662-66.
Sharma N, Sharma A. Thyroid profile in menstrual disorders. JK Sci. 2012; 14: 14-17.
Singh B, Sundar S, Shukla A. Herbal medicines for thyroid diseases In: Treating endocrine and metabolic disorders with herbal medicines. India, IGI Global, 2021, pp 256-77.
Siriwardene SAD, Karunathilaka LPA, Kodituwakku ND, Karunarathne YAUD. Clinical efficacy of ayurveda treatment regimen on subfertility with polycystic ovarian syndrome (PCOS). J Ayurveda Integr Med. 2010; 31: 24-27.
Snafi AAE. Arabian medicinal plants with analgesic and antipyretic effects-plant based review (Part 1). IOSR J Pharm. 2018; 8: 81-102.
Swaroop A, Jaipuriar AS, Gupta SK, Bagchi M, Kumar P, Preuss HG, Bagchi D. Efficacy of a novel fenugreek seed extract (Trigonella foenum-graecum, FurocystTM) in polycystic ovary syndrome (PCOS). Int J Med Sci. 2015; 12: 825-31.
Szanto I, Pusztaszeri M, Mavromati M. H2O2 metabolism in normal thyroid cells and in thyroid tumorigenesis: Focus on NADPH oxidases. Antioxidants 2019; 8: 126
Tahiliani P, Kar A. The combined effects of Trigonella and Allium extracts in the regulation of hyperthyroidism in rats. Phytomedicine 2003; 10: 665-68.
Tiwari P, Kumar B, Kaur M, Kaur G, Kaur H. Phytochemical screening and extraction: A review. Int Pharm Sci. 2011; 1: 98-106.
Udoh P, Nju R, Udoh F. Effect of Carica papaya (pawpaw) seeds ethanolic extract on the pituitary, thyroid and parathyroid glands of male Wistar rats. Global J Pure Appl Sci. 2004; 10: 515-17.
Ugochukwu SC, Arukwe Uche I, Ifeanyi O. Preliminary phytochemical screening of different solvent extracts of stem bark and roots of Dennetia tripetala G. Baker. Asian J Plant Sci Res. 2013; 3: 10-13.
Vargas ML, Almario RU, Buchan W, Kim K, Karakas SE. Metabolic and endocrine effects of long-chain versus essential omega-3 polyunsaturated fatty acids in polycystic ovary syndrome. Metabolism 2011; 60: 1711-18.
Velavan S. Phytochemical techniques: A review. World J Sci Res. 2015; 1: 80-91.
Wang JG, Anderson RA, Graham GM, Chu MC, Sauer MV, Guarnaccia MM, Lobo RA. The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: A pilot study. Fertil Steril. 2007; 88: 240-43.
Wiersinga WM, Poppe KG, Effraimidis G. Hyperthyroidism: Aetiology, pathogenesis, diagnosis, management, complica-tions and prognosis. Lancet Diabetes Endocrinol. 2023; 11: 282-98.
Yadav R, Agarwala M. Phytochemical analysis of some medicinal plants. J Phytol. 2011; 3: 10-14.
Zaheer M, Ahmed S, Hassan MM. A review of medicinal uses, phytochemistry and pharmacology of Vigna mungo (L.) Hepper. J Pharmacogn Phytochem. 2020; 9: 1307-09.
Zangeneh FZ, Minaee B, Amirzargar A, Ahangarpour A, Mou-savizadeh K. Effects of chamomile extract on biochemical and clinical parameters in a rat model of polycystic ovary syndrome. J Reprod Infertil. 2010; 11: 169-74.
Zohra SF, Meriem B, Samira S, Muneer M. Phytochemical screening and identification of some compounds from mallow. J Nat Prod Plant Resour. 2012; 2: 512-16.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Mariya Anwaar, Qaiser Jabeen, Hina Ali, Ayesha Nadeem, Hafiz Muhammad Farhan Rasheed
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
