Hepatoprotective effect of Garcinia xanthochymus and Garcinia lanceifolia against carbon tetrachloride-induced hepatic damage in rat
DOI:
https://doi.org/10.3329/bjp.v18i3.65992Keywords:
Garcinia lanceafolia, Garcinia xanthocymus, HepatoprotectiveAbstract
Garcinia xanthocymus and Garcinia lanceifolia fruit extracts (200 or 400 mg/kg in each plant) were used to evaluate the hepatoprotective activity in albino rats. The carbon tetrachloride-intoxicated group initially elevated the liver marker enzymes (serum aminotransferases, alkaline phosphatase) and bilirubin. Total protein production was suppressed. When extracts were administered orally, it lowered the level of liver marker enzymes, bilirubin and elevated the production of protein. The histopathological findings supported the hepatoprotective activity of both extracts at tissue level. In conclusion, the fruit rind extract of G. xanthocymus and G. lanceifolia has protective effect on carbon tetrachloride-induced liver injury.
Downloads
7
5
References
Achliya GS, Kotagale NR, Wadodkar SG, Dorle AK. Hepatoprotective activity of Panchagavya ghrita against carbon tetrachloride-induced hepatotoxicity in rats. Indian J Pharmacol. 2003; 35: 308-11.
Akbar S, Ishtiaq S. Hepatoprotective effect of Misopates orontium in rats. Bangladesh J Pharmacol. 2020; 15: 75-81.
Babu BH, Shylesh BS, Padikkala J. Antioxidant and hepatoprotective effect of Acanthus ilicifolius. Fitoterapia 2001; 72: 272-77.
Biswas M, Karan TK, Kar B, Bhattacharya S, Ghosh AK, Kumar RBS, Haldar PK. Hepatoprotective activity of Terminlia arjuna leaf against paracetamol induced liver damage in rats. Asian J Chem. 2011; 23: 1739-42.
Burkill IH. A dictionary of economic product of the Malay Peninsula. 1st ed. London, Government of straits settlement, 1935.
Charlton MR. Protein metabolism and liver disease. Baillieres Best Pract Res Clin Endocrinol. 1996; 10: 617-35.
Galigher AE, Kozloff EN, Essentials of practical microtechniques. 2nd ed. Lea and Febiger, 1971.
Gogoi N, Gogoi A, Neog B. Free radical scavenging activities of Garcinia xanthochymus Hook. f. and Garcinia lanceaefolia Roxb. using various in vitro assay models. Asian J Pharm Clin Res. 2015; 9: 138-41.
Gogoi N, Gogoi A, Neog B, Baruah D, Singh KD. Evaluation of antioxidant and hepatoprotective activity of fruit rind extract of Garcinia dulcis (Roxburgh) Kurz. Phcog Res. 2017; 9: 266-72.
Gogoi N. Evaluation of hepatoprotective activity of Garcinia species and its genetic diversity in Upper Assam with special reference to Garcinol. Ph.D. thesis, Dibrugarh University, 2019.
Gogoi N, Gogoi A, Neog B. Assessment of Antioxidant Activity of Garcinol Derived from Garcinia xanthochymus Hook. f. Indian J Nat Sci.2020; 63: 28485-91
Gogoi N, Gogoi A, Neog B, Baruah D, Singh KD. Antioxidant and hepatoprotective activity of fruit rind extract of Garcinia morella (Gaertn.) Desr. IJNPR. 2017; 8: 132-39.
Jamila N, Khan N, Khan AA, Khan I, Khan SN, Zakariae ZA, Kim KS. and in vitro cytotoxic activities of Garcinia hombro-niana (seashore 372 mangosteen). Afr J Tradit Complement Altern Med. 2017; 14: 374-82.
Kadiiska MB, Gladen BC, Baird DD, Dikalova AE, Sohal RS, Hatch GE, Jones DP, Mason RP, Barrett JC. Biomarkers of oxidative stress study: Are plasma antioxidants markers of CCl4 poisoning? Free Radic Biol Med. 2000; 28: 838-45.
Kamraj VP. Herbal medicine. Curr Sci. 2000; 78: 35-39.
Kaplowitz N, Aw TY, Simon FR, Stolz A. Drug-induced hepatotoxicity. Ann Intern Med. 1986; 104: 826-39.
King EJ, Kind RP. Alkaline phosphatase activity assay. J Clin Pathol. 1954; 7: 332.
Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951; 193: 265-75.
Malloy HT, Evelyn KA. The determination of bilirubin with the photoelectric colorimeter. J Biol Chem. 1937; 119: 481-90.
Mandal SC, Saraswathi B, Ashok Kumar CK, Mohana Lakshmi S, Maiti BC. Protective effect of leaf extract of Ficus hispida Linn. against paracetamol‐induced hepatotoxicity in rats. Phytother Res. 2000; 14: 457-59.
Mundugaru, R, Chakkravarthy, M, Basavaiah, R. Hepatopro-tective activity of fruit extract Garcinia pedunculata. Bangladesh J Pharmacol. 2014; 9: 483-87.
Moss DW , Butterworth PJ. Enzymology and medicine. London, Pitman Medical, 1974, p 39.
Muriel P, Mourelle M. Prevention by silymarin of membrane alterations in acute CCl4 liver damage. J Appl Toxicol. 1990; 10 : 275-79.
Naik SR, Panda VS. Antioxidant and hepatoprotective effects of Ginkgo biloba phytosomes in carbon tetrachloride‐induced liver injury in rodents. Liver Int. 2007; 27: 393-99.
OECD, Guidelines for testing of chemicals, acute oral toxicity, environmental health and safety monograph series on testing and adjustment. No. 425, 2011.
Rao GM, Rao CV, Pushpangadan P, Shirwaikar A. Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn. J Ethnopharmacol. 2006; 103: 484-90.
Reitman S, Frankel S. A calorimetric method for the determination of serum glutamate oxaloacetate and glutamate pyruvate transaminase. Am J Clin Path .1957; 28: 53-56.
Singh K, Khanna AK, Chander R. Hepatoprotective activity of ellagic acid against carbon tetrachloride-induced hepatotoxicity in rats. Indian J Exp Biol. 1999; 37: 1025-26.
Smith YRA, Adanlawo IG. Protective effect of saponin extract from the root of Garcinia kola (bitter kola) against paracetamol-induced hepatotoxicity in Albino rats. Int J Sci Res Innov. 2015; 9: 130-34.
Sun F, Hamagawa E, Tsutsui C, Ono Y, Ogiri Y, Kojo S. Evaluation of oxidative stress during apoptosis and necrosis caused by carbon tetrachloride in rat liver. BBA-Mol Basis Dis. 2001; 1535: 186-91
Wiseman H, Halliwell B. Damage to DNA by reactive oxygen and nitrogen species: Role in inflammatory disease and progression to cancer. Biochem J. 1996; 313: 17-29.
Van Puyvelde L, Kayonga A, Brioen P, Costa J, Ndimubakunzi A, De Kimpe N, Schamp N. The hepatoprotective principle of Hypoestes triflora leaves. J Ethnopharmacol. 1989; 26: 121-27.
Yamaguchi F, Ariga T, Yoshimura Y, Nakazawa H. Antioxidative and antiglycation activity of garcinol from Garcinia indica fruit rind. J Agric Food Chem. 2000; 48: 180-85.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Nabajyoti Gogoi, Ankur Gogoi, Bijoy Neog, Khumanthem Deepak Singh
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
