Hepatoprotective effect of Garcinia xanthochymus and Garcinia lanceifolia against carbon tetrachloride-induced hepatic damage in rat
DOI:
https://doi.org/10.3329/bjp.v18i3.65992Keywords:
Garcinia lanceafolia, Garcinia xanthocymus, HepatoprotectiveAbstract
Garcinia xanthocymus and Garcinia lanceifolia fruit extracts (200 or 400 mg/kg in each plant) were used to evaluate the hepatoprotective activity in albino rats. The carbon tetrachloride-intoxicated group initially elevated the liver marker enzymes (serum aminotransferases, alkaline phosphatase) and bilirubin. Total protein production was suppressed. When extracts were administered orally, it lowered the level of liver marker enzymes, bilirubin and elevated the production of protein. The histopathological findings supported the hepatoprotective activity of both extracts at tissue level. In conclusion, the fruit rind extract of G. xanthocymus and G. lanceifolia has protective effect on carbon tetrachloride-induced liver injury.
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