Effect of Cuminum cyminum and Rhus pentaphylla extracts on status epilepticus induced by intrahippocampal injection of kainic acid in rat

Authors

  • Khadija Oubella Laboratory of Pharmacology, Neurobiology, Anthropology and Environment, Department of Biology, Faculty of Sciences Semlalia, University Cadi Ayyad, BP 2390 40080 Marrakech, Morocco.
  • Karima Benrazzouk Laboratory of Agri-Food, Biotechnology, and Valorization of Plant Resources; Phytochemistry and Pharmacology of Medicinal Plants Unit, Faculty of Sciences Semlalia, Cadi Ayyad University, Marrakech, Morocco.
  • Abdellah Bagri Laboratory of Biochemistry and Neuroscience, Integrative and Computational Neuroscience Team, Faculty of Sciences and Technology, Hassan First University, Settat 26002, Morocco.
  • Abderrahman Chait Laboratory of Pharmacology, Neurobiology, Anthropology and Environment, Department of Biology, Faculty of Sciences Semlalia, University Cadi Ayyad, BP 2390 40080 Marrakech, Morocco. https://orcid.org/0000-0002-5639-1931

DOI:

https://doi.org/10.3329/bjp.v18i3.67165

Keywords:

Anticonvulsant, Antioxidant, Epilepsy, Kainic acid

Abstract

This study aims to evaluate the anticonvulsant effect of the aqueous extract of Rhus pentaphylla and Cuminum cyminum (300 mg/kg), orally, 45 min before intrahippocampal injection of kainic acid (1 µg/µL). The scoring of seizure severity, latency of seizures and duration of total seizures were recorded in 90 min. Both extracts showed the presence of polyphenols, flavonoids, alkaloids and tannins compounds. These extracts exhibited potent antioxidant activity and showed an attenuation of severe convulsive seizures, a significant decrease in the frequency and duration of seizures and prolonged the latency of the onset seizure (p<0.001) compared to kainic acid. The aqueous extracts of R. pentaphylla and C. cyminum have a protective effect against seizures induced by kainic acid.

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Published

2023-08-21

How to Cite

Oubella, K. ., K. . Benrazzouk, A. . Bagri, and A. Chait. “Effect of Cuminum Cyminum and Rhus Pentaphylla Extracts on Status Epilepticus Induced by Intrahippocampal Injection of Kainic Acid in Rat”. Bangladesh Journal of Pharmacology, vol. 18, no. 3, Aug. 2023, pp. 105-12, doi:10.3329/bjp.v18i3.67165.

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Research Articles