Neurobehavioral assessment of seed extract of Swietenia mahagoni on zebrafish model
DOI:
https://doi.org/10.3329/bjp.v18i4.67354Keywords:
Light-Dark Test, Mirror Bite Test, Neurobehavioral Study, Open Field Test, Predator Avoidance Test, Swietenia MahagoniAbstract
Traditional medicine in tropical areas often includes the use of Swietenia mahagoni to treat a wide range of conditions. However, preclinical testing is crucial to ensure their safety profile and address any remaining concerns about their efficacy. The zebrafish model of open field test shows that decreased dopamine and cholinergic transmission causes impaired locomotion and diminished exploratory behavior. In addition to the elevation of 5-HT and GABA reported in the mirror bite test findings, the extract may have suppressed dopamine expression. The mirror-bite test and the light-dark test both showed elevated levels of GABA expression. Findings from the predator avoidance test are very suggestive of a neurotransmitter-regulating action of the extract.
Downloads
5
5
References
Ablain J, Zon LI. Of fish and men: Using zebrafish to fight human diseases. Trends Cell Biol. 2013; 23: 584-86.
Abubakar AR, Haque M. Preparation of medicinal plants: Basic extraction and fractionation procedures for experimental purposes. J Pharm Bioallied Sci. 2020; 12: 1.
Alzweiri M, Sweidan K, Saleh OA, Al-Helo T. Synthesis and evaluation of new 2-oxo-1, 2-dihydroquinoline-3-carboxamides as potent inhibitors against acetylcholinesterase enzyme. Med Chem Res. 2022; 31: 1448-60.
Bass SL, Gerlai R. Zebrafish (Danio rerio) responds differentially to stimulus fish: The effects of sympatric and allopatric predators and harmless fish. Behav Brain Res. 2008; 186: 107-17.
Eid AM, Elmarzugi NA, El-Enshasy HA. A review on the phytopharmacological effect of Swietenia macrophylla. Int J Pharm Pharm Sci. 2013; 5: 47-53.
Firdous SM, Ahmed S, Dey S. Antiepileptic and central nervous system depressant activity of Sechium edule fruit extract. Bangladesh J Pharmacol. 2012; 7: 199-202.
Gerlai R. Zebrafish antipredatory responses: A future for translational research?. Behav Brain Res. 2010; 207: 223-31.
Jones LJ, Norton WH. Using zebrafish to uncover the genetic and neural basis of aggression, a frequent comorbid symptom of psychiatric disorders. Behav Brain Res. 2015; 276: 171-80.
Lama M, Chatterjee M, Chaudhuri TK. A study of the association of childhood asthma with HLA alleles in the population of Siliguri, West Bengal, India. Tissue Antigens. 2014; 84: 316-20.
Liu XJ, Wang HJ, Wang XY, Ning YX, Gao J. GABABR1 in DRN mediated GABA to regulate 5-HT expression in multiple brain regions in male rats with high and low aggressive behavior. Neurochem Int. 2021; 150: 105180.
Magyary I. Recent advances and future trends in zebrafish bioassays for aquatic ecotoxicology. Ecocycles 2018; 4: 12-18.
Maqbool S, Younus I. Anxiolytic and hypnotic effects of Cocculus laurifolius leaf extract in mice. Bangladesh J Pharmacol. 2019; 14: 45-53.
Maximino C, Benzecry R, Oliveira KR, Batista ED, Herculano AM, Rosemberg DB, de Oliveira DL, Blaser R. A comparison of the light/dark and novel tank tests in zebrafish. Behaviour 2012; 149: 1099-23.
McAllister TW. Neurobehavioral sequelae of traumatic brain injury: Evaluation and management. World Psychiatry. 2008; 7: 3.
Mhalhel K, Sicari M, Pansera L, Chen J, Levanti M, Diotel N, Rastegar S, Germanà A, Montalbano G. Zebrafish: A model deciphering the impact of flavonoids on neurodegenerative disorders. Cells. 2023; 12:252.
Ogi A, Licitra R, Naef V, Marchese M, Fronte B, Gazzano A, Santorelli FM. Social preference tests in zebrafish: A systematic review. Front Vet Sci. 2021; 7: 590057.
Panda SP, Haldar PK, Bera S, Adhikary S, Kandar CC. Antidiabetic and antioxidant activity of Swietenia mahagoni in streptozotocin-induced diabetic rats. Pharm Biol. 2010; 48: 974-79.
Prut L, Belzung C. The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: A review. Eur J Pharmacol. 2003; 463: 3-33.
Sahgal G, Ramanathan S, Sasidharan S, Mordi MN, Ismail S, Mansor SM. In vitro antioxidant and xanthine oxidase inhibitory activities of methanolic Swietenia mahagoni seed extracts. Molecules. 2009; 14: 4476-85.
Sahgal G, Ramanathan S, Sasidharan S, Mordi MN, Ismail S, Mansor SM. Brine shrimp lethality and acute oral toxicity studies on Swietenia mahagoni (Linn.) Jacq. seed methanolic extract. Pharmacog Res. 2010; 2: 215.
Saluja D, Jhanji R, Kaushal S, Verma B, Sharma N, Singh R, Agrawal S, Yadav M, Kumar A, Singh C, Singh A. Importance of zebrafish as an efficient research model for the screening of novel therapeutics in neurological disorders. CNS Neurol Disord Drug Targets. 2021; 20: 145-57.
Sofowora A, Ogunbodede E, Onayade A. The role and place of medicinal plants in the strategies for disease prevention. Afr J Tradit Complement Altern Med. 2013; 10: 210-29.
Souza TP, Franscescon F, Stefanello FV, Müller TE, Santos LW, Rosemberg DB. Acute effects of ethanol on behavioral responses of male and female zebrafish in the open field test with the influence of a non-familiar object. Behav Processes. 2021; 191: 104474.
Spinello C, Yang Y, Macrì S, Porfiri M. Zebrafish adjust their behavior in response to an interactive robotic predator. Front Robot AI. 2019; 38: 1-14.
Stewart A, Gaikwad S, Kyzar E, Green J, Roth A, Kalueff AV. Modeling anxiety using adult zebrafish: A conceptual review. Neuropharmacology 2012; 62: 135-43.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Sourav Pal, Subhajit Mandal, Sayed Mohammed Firdous
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
