Aqueous extracts of the leaves of Sesbania sesban reduces development of diabetic nephropathy in streptozotocin-induced diabetic rat
DOI:
https://doi.org/10.3329/bjp.v5i2.7592Keywords:
HbA1c, Albuminuria, proteinuria, Diabetic nephropathy, Sesbania sesban.Abstract
The renal protective effect of the aqueous extract of Sesbania sesban leaves (250 and 500 mg/kg/day) in streptozotocin-induced diabetic rats were studied. Diabetic rats showed severe hyperglycemia with marked increase in proteinuria and albuminuria. Thye aqueous extract reduced proteinuria, albuminuria, lipid and glycated hemoglobin (HbA1c) deposition in diabetic rats. Histopathology studies on kidneys of diabetic rats revealed severe increase in mesangial cells and matrix of glomeruli with hyaline thickening of some arteriole wall, resulted from selective albuminuria and proteinuria. These changes are inhibited by the extract and glibenclamide. These results suggested that aqueous extract of S. sesban has reduced development of diabetic nephropathy in streptozotocin-induced diabetic rats.
Downloads
231
96 Read
2
References
Akhtar MS, Ali MR. Study of antidiabetic effect of a compound medicinal plant prescription in normal and diabetic rabbits. J Pak Med Assoc. 1984; 34: 239-44.
Alberti KGMM, CM. Press, The biochemistry and the complications of diabetes In: Complications of diabetes. Keen H, Jarrett J (eds), vol. 43. Edward Arnold Ltd., London, 1982, pp 231-70.
Burrows NR, Wang J, Geiss LS, Venkat Narayan KM, Engelgau MM. Incidence of end-stage renal disease among persons with diabetes e United States, 1990-2002. MMWR Weekly. 2005; 54: 1097-100.
Burstein M, Scholnichk HR, Morin R. Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J Lipid Res. 1970; 11: 583-95.
Chatterjea MN, Shinde R. Diabetes mellitus: Textbook of medical biochemistry. 5th ed. Jaypee Brothers Medical Publishers Ltd., New Delhi, 1976.
El-Sayed NH. A rare kaempferol trisaccharide anti-tumor promoter from Sesbania sesban. Pharmazie 1991; 46, 679-80.
Eross J, Kreutzman D, Jimenez M, Keen R, Rogers S, Cowell C, Vines R, Silink M. Colorimetric measurement of glycosylated protein in whole blood cells plasma and dried blood. Ann Clin Biochem. 1984; 21: 519-22.
Folch J, Lees M, Solane SGH. A simple method for isolation and purification of total lipids from animal tissues. J Biol Chem. 1957; 26: 497-09.
Foster JB, Dunn RT. Stable reagents for determination of serum triglycerides by colorimetric Hantzsch condensation method. Clin Chem. 1973; 19: 338-40.
Friedwald WT, Levy RI, Fredrickson DS. Estimation of the concentration of LDL-cholesterol in plasma without the use of the preparative ultracentrifuge. Clin Chem. 1972; 18: 499-502.
Gupta S, Kataria M, Gupta PK, Murganandan S, Yashroy RC. Protective role of extracts of neem seeds in diabetes caused by streptozotocin in rats. J Ethnopharmacol. 2004; 90: 185-89.
Hink U, Li H, Mollnau H. Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res. 2001; 88: e14-22.
Jain SR, Hypoglycemic principal in the Musa sapeintum and its isolation. Planta Medica. 1968; 1: 43-47.
Kesari AN, Gupta RK, Watal G. Hypoglycemic effects of Murraya koenigii on normal and alloxan diabetic rabbits. J Ethnopharmacol. 2005; 97: 247-51.
Khare CP. Indian medicinal plants: An illustrated dictionary. Springer, Verlag Berlin, 2007, p 601.
Leese GP, Savage MW, Chattington PD, Vora JP. The diabetic patient with hypertension. Postgraduate Med J. 1996; 72, 263-68.
Pari L, Saravanan G. Antidiabetic effect of Cogent db, a herbal drug in alloxan-induced diabetes mellitus. Comp Biochem Physiol. C: Pharmacol Toxicol Endocrinol. 2002; 131: 19-25.
Ramdas B. Pandhare, B. Sangameswaran, Popat B. Mohite, Shantaram G. Khanage. Antidiabetic activity of aqueous leaves extract of Sesbania sesban (L) Merr. in streptozotocin-induced diabetic rats. 2011; 3: 37-43.
Schnachenberg CG. Oxygen radicals in cardiovascularerenal disease. Curr Opin Pharmacol. 2002; 2: 121-25.
Sohn EJ, Kim CS, Kim YS, Jung DH, Jang DS, Lee YM, Kim JS. Effects of magnolol (5,50-diallyl-2, 20-dihydroxybiphenyl) on diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats. Life Sci. 2007; 80: 468-75.
Susztak K, Raff AC, Schiffer M. Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes 2006; 55: 225-33.
Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. Traditional plant treatment for diabetes: studies in normal and streptozotocin diabetic mice. Diabetologia 1990; 33: 462-64.
Upadhyaya JS, Singh SP. Chromatographic studies of oxidation products of lignin from Sesbania sesban. Cellul Chem Technol. 1991; 25: 219-26.
Yusuf M, Chowdhury JU, Wahab MA, Begum J. Medicinal plants of Bangladesh. BCSIR, Dhaka, Bangladesh. 1994, p 223.
Zlatkis A, Zak B, Boyle AJ. A new method for the direct determination of serum cholesterol. J Lab Clin Med. 1953; 41: 48692.
Additional Files
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
