In vitro anti-cancer and antimicrobial activities of Abelmoschus esculentus root extracts
DOI:
https://doi.org/10.3329/bjp.v20i1.80757Keywords:
Abelmoschus esculentus, Anti-cancer, AntimicrobialAbstract
This study explored the potential of Abelmoschus esculentus for treating oral squamous cell carcinoma and associated risk factors. The extract, obtained via soxhlet extraction, was formulated into a carbopol 940 gel for topical and oral mucosal delivery. Phytochemical screening revealed alkaloids, flavonoids, carbohydrates, and phenolic compounds. The Folin-Ciocalteu method showed high total phenolic content (R²=0.9953). The extract exhibited promising in vitro anti-cancer activity against a squamous cell carcinoma cell line, achieving a 52.9% inhibition rate at the highest concentration 100 µg/mL. Additionally, the extract demonstrated potential antibacterial activity against Helicobacter pylori ATCC 43501 compared to clarithromycin. The extract-loaded gel formulation with 1.5% carbopol was developed, exhibiting optimal viscosity (1245 cps) and a suitable pH (6.45) for topical use.
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Copyright (c) 2025 Akash Desai, Manure Md. Javeed Md. Yakub, Priti Karade, Sudhir S. Patil
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