Antiproliferative activity of Tribulus terrestris stem bark extract against A431 cells

Authors

  • Ravindra Gaikwad Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Palus 416310, India.
  • Anilkumar Shinde Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur 416013, India
  • Sameer Nadaf Bharati Vidyapeeth College of Pharmacy, Palus

DOI:

https://doi.org/10.3329/bjp.v20i3.83249

Keywords:

Apoptosis, Antiproliferative, A431 cell, Tribulus terrestris

Abstract

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References

Abbas MW, Hussain M, Akhtar S, Ismail T, Qamar M, Shafiq Z, Esatbeyoglu T. Bioactive compounds, antioxidant, anti-inflammatory, anti-cancer, and toxicity assessment of Tribulus terrestris: In vitro and in vivo studies. Antioxidants 2022; 11: 1160.

Alshabi AM, Alkahtani SA, Shaikh IA, Orabi MA, Abdel-Wahab BA, Walbi IA, Habeeb MS, Khateeb MM, Shettar AK, Hoskeri JH. Tribulus terrestris cytotoxicity against breast cancer MCF-7 and lung cancer A549 cell lines is mediated via activation of apoptosis, caspase-3, DNA degradation, and suppressing Bcl-2 activity. Separations 2022; 9: 383.

Amanullah KZ, Zeenat F, Ahmad W, Firoz S, Naeela A. A comprehensive review on a Unani medicinal plant: Tribulus terrestris Linn. Int J Herb Med. 2021; 9: 23-28.

Bahuguna A, Khan I, Bajpai VK, Kang SC. MTT assay to evaluate the cytotoxic potential of a drug. Bangladesh J Pharmacol. 2017; 12: 115-18.

Chhatre S, Nesari T, Somani G, Kanchan D, Sathaye S. Phyto-pharmacological overview of Tribulus terrestris. Phcog Rev. 2014; 8: 45.

Dabaghkar Y, Eghlima G, Behboudi H, Ebrahimi M, Ghorban-pour M. Agro-morphological characterization and assess-ment of metabolic profiling and anticancer activities in various tribulus (Tribulus terrestris L.) populations. BMC Plant Biol. 2025; 25: 20.

Das N, Goshwami D, Hasan MS, Al Mahmud Z, Raihan SZ. Evaluation of antioxidant, antimicrobial and cytotoxic acti-vities of Terminalia citrina leaves. J Pharm Res. 2016; 10: 8-15.

Figueiredo CCM, Gomes AC, Granero FO, Bronzel Junior JL, Silva LP, Ruiz ALTG, da Silva RMG. Antiglycation and antitumoral activity of Tribulus terrestris dry extract. Avi-cenna J Phytomed. 2021; 11: 224-37.

Gaikwad R, Shinde A. Antiproliferative effect of Memecylon malabaricum leaves methanolic extract against A-431 cell lines. Bangladesh J Pharmacol. 2022; 17: 54-55.

Gaikwad RG, Shinde AJ, Hajare AA. Herbal treatment for management of psoriasis: An overview. RJPT. 2022; 15: 1385-92.

Johnston JB, Navaratnam S, Pitz MW, Maniate JM, Wiechec E, Baust H, Gingerich J, Skliris GP, Murphy LC, Los M. Targeting the EGFR pathway for cancer therapy. Curr Med Chem. 2006; 13: 3483-92.

Neychev VK, Nikolova E, Zhelev N, Mitev VI. Saponins from Tribulus terrestris L. are less toxic for normal human fibroblasts than for many cancer lines: Influence on apoptosis and proliferation. EBM. 2007; 232: 126-33.

Pourali M, Yaghoobi MM, Sormaghi MH. Cytotoxic, anti-proliferative and apoptotic effects of Tribulus terrestris L. fruit extract on human prostate cancer Lncap and colon cancer HT-29 Cell Lines. Jundishapur J Nat Pharm Prod. 2017; 1; 12: e33561.

Zheng L, He H, Shen X, Sun Y. Centipede scolopendra suppresses cell growth in human epidermoid carcinoma cell A431. Bangladesh J Pharmacol. 2017; 12: 299-307.

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Published

2025-09-04

How to Cite

Gaikwad, Ravindra, et al. “Antiproliferative Activity of Tribulus Terrestris Stem Bark Extract Against A431 Cells”. Bangladesh Journal of Pharmacology, vol. 20, no. 3, Sept. 2025, pp. 131-3, doi:10.3329/bjp.v20i3.83249.

Issue

Vol. 20 No. 3 (2025)

Section

Letter to the Editor

License

Copyright (c) 2025 Ravindra Gaikwad, Anilkumar Shinde, Sameer Nadaf

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