Impact of prophylactic use of antimicrobials in abdominal surgery in two tertiary level hospitals
DOI:
https://doi.org/10.3329/bjp.v3i2.837Keywords:
Antimicrobial, Cephalosporin, Ciprofloxacin, Metronidazole, SurgeryAbstract
Post-surgical infections are polymicrobial and it is an important cause of morbidity and mortality. The combination of ciprofloxacin plus metronidazole as well as several ß-lactum based regimens are commonly used regimens for the treatment of patients with such infections. Three hundred patients (age range 25-40 years) were taken from two teaching hospitals for interventional study. When patients were selected for appenditectomy or cholecystectomy, either ciprofloxacin plus metronidazole or cephalosporin plus metronidazole were given intravenously. The patients were then divided into 4 groups. Group I and Group II received drugs ciprofloxacin plus metronidazole and cephalosporin plus metronidazole in SSMC respectively and Group III and Group IV received drugs ciprofloxain plus metronidazole and cephalosporin plus metronidazole in DNMC respectively. There were 33 cases of infections out of total 300 study subjects. It was observed that in SSMC among ciprofloxacin plus metronidazole; the rate of infection was 10.6% and cephalosporin plus metronidazole group was 14.6% while that in DNMC the rate were 8% and 10.6% respectively. The overall rate of infection was 11%.
Downloads
872
611 Read
137
References
Koch R, Hippocrates G. Wound infection. In: Baily & Loves short practice of surgery. Russell RCG, Williams NS, Bulstrode CJK (eds). 24th ed. London, Arnold, 2004, pp 118-32.
Kaiser AB. Antimicrobial prophylaxis in surgery. Medical Intelligence. 1986; 315: 1129-36.
Chambers HF. Beta-lactam and other cell wall- and membrane-active antibiotics. In: Basic and clinical pharmacology. Katzung BG (ed). 10th ed. 2007, pp 726-44.
Martin TC, Anthony F. Antibiotic use and overuse for appendisectomy in Antigua and Barbude. West Indian Med J. 1999; 47: 1-7.
Mathaiou DK, Peppas G, Bliziotis I, Falagas ME. Ciprofloxacin/metronidazole versus ?-lactum based treatment of itnra-abdominal infection: A meta-analysis of comparative trials. Elsevier B, V and International Society of Chemotherapy, 2006.
Nichols RL. Preventing surgical site infections: A surgeons perspective. Emerg Infec Dis. 2001; 7: 220-24.
Nichols RL. Use of prophylactic antibiotics in surgical practice. Am J Med. 1981; 70: 686-92.
Rahman Z. Pattern of use of prophylactic antimicrobial in total abdominal hysterectomy; use of a single dose prophylactic antibiotic in routine abdominal hysterectomy: A randomized controlled trial in SSMC&MH. Dhaka, MPhil Thesis, 2005
Relman AS, Angell M, Selzman EW. Post-operative wound infection. New Engl J Med. 1982; 307: 1701-02.
Trevor AJ, Katzung BG, Masters SB. Clinical use of antimicrobials. Katzung & Trevors pharmacology: Examination & Board Review. 6th ed. 2002, p 450.
Additional Files
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
