Diuretic effect of Caesalpinia bonduc in rats

Authors

  • Ajay Khedkar Department of Pharmacognosy and Phytochemistry, KLEUs College of Pharmacy, Belgaum
  • Yuvaraj D. Mandavkar Department of Pharmacognosy and Phytochemistry, KLEUs College of Pharmacy, Belgaum
  • Gulab Shinde Department of Pharmacognosy and Phytochemistry, KLEUs College of Pharmacy, Belgaum
  • Pallavi Khalure Department of Pharmacognosy and Phytochemistry, KLEUs College of Pharmacy, Belgaum
  • Pravin Dere Department of Pharmacognosy and Phytochemistry, KLEUs College of Pharmacy, Belgaum

DOI:

https://doi.org/10.3329/bjp.v6i1.8487

Keywords:

Caesalpinia bonduc, Diuretic, Herbal, Medicinal plant

Abstract

The diuretic effect of aqueous and methanol extracts of the dried seeds of Caesalpinia bonduc was studied in normal rats. Extracts were administered orally at two doses and furosamide was used as standard drug. Urine volume was significantly increased by the two doses of aqueous and methanol extracts in comparison to control group. While the excretion of sodium was also increased by both extracts, potassium excretions were only increased by the aqueous and methanol extracts at a higher dose. The present study provides a quantitative basis for explaining the use of seeds extracts of C. bonduc as a diuretic agent.

Downloads

Download data is not yet available.
Abstract
338
Download
403 Read
5

References

Biswas TK, Bandyopadhyay S, Mukherjee B, Sengupta BR. Oral hypoglycemic effect of Caesalpinia bonducella. Int J Pharmacog. 1997; 35: 261-64.

Dhar ML, Dhar MM, Dhawan BN, Mehrotra BN, Roy C. Screening of Indian plants for biological activity. Indian J Exp Biol. 1968; 6: 232-47.

Gayaraja S, Shinde S, Agarwal SL. Antiasthmatic properties of Caesalpinia bonducella leaves. Indian J Pharmacol. 1978; 10: 86-89.

Jouad H, Haloui M, Rhiouani H, El Hilaly J, Eddouks M. Ethnobotanical survey of medicinal plants used for the treatment of diabetes, cardiac and renal diseases in the North centre region of Morocco (Fez-Boulemane). J Ethnopharmacol. 2001; 77: 175-82.

Kau ST, Keddi, JR, Andrews D. A method for screening diuretic agents in the rats. J Pharmacol Meth. 1984; 11: 6775.

Maghrani M, Zeggwagh N, Haloui M, Eddouks M. Acute diuretic effect of aqueous extract of Retama raetam in normal rats. J. Ethnopharmacol. 2005; 99: 3135.

Nadakarni AK, Nadakarni KR. Indian Materia Medica; Bombay, Popular Prakashan, 1999, p 226.

OECD. Guidelines for testing of chemicals. Revised draft guidelines 423. Acute oral toxicity class method. October 2000.

Pantoja CV, Chiang LCH, Norris BC, Concha JB. Diuretic, natriuretic and hypotensive effects produced by Allium sativum (garlic) in anaesthetized dogs. J Ethnopharmacol. 1993; 31: 32531.

Raghunathan, K, Mitra R. Pharmacognosy of indigenous drugs. New Delhi, Central Council for Research in Ayurveda and Siddha, 1982, pp 484-510.

Rao VV, Dwivedi SK, Swarup D. Hypoglycemic effect of Caesalpinia bonducella in rabbits. Fitoterapia 1994; 65: 245-47.

Sharma SR, Dwivedi SK, Swarup D. Hypoglycemic, antihyperglycemic and hypolipidemic activities of Caesalpinia bonducella seeds in rats. J Ethnopharmacol. 1997; 58: 39-44.

Stanic G, Samarzija I. Diuretic Activity of Satureja montana subsp. montana extracts and oil in rats. Phytother Res. 1993; 7: 36366.

Downloads

Additional Files

Published

2011-09-20

How to Cite

Khedkar, A., Y. D. Mandavkar, G. Shinde, P. Khalure, and P. Dere. “Diuretic Effect of Caesalpinia Bonduc in Rats”. Bangladesh Journal of Pharmacology, vol. 6, no. 1, Sept. 2011, pp. 61-63, doi:10.3329/bjp.v6i1.8487.

Issue

Vol. 6 No. 1 (2011)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).