Synthesis and anticonvulsant activity of Schiff’s bases of 3-{[2-({(E)-[(substituted) phenyl] methylidene} amino) ethyl] amino} quinoxalin-2(1H)-one

Authors

  • Ratnadeep V. Ghadage Department of Pharmaceutical Chemistry, Appasaheb Birnale College of Pharmacy, South Shivaji Nagar, Sangli 416416
  • Pramod J. Shirote Department of Pharmaceutical Chemistry, Appasaheb Birnale College of Pharmacy, South Shivaji Nagar, Sangli 416416

DOI:

https://doi.org/10.3329/bjp.v6i2.8671

Keywords:

Anti-covulsant, Microwave method, Phillips condensation, Quinoxaline, Schiff’s bases,

Abstract

In an effort to develop potent anticonvulsant agents, we have synthesized some novel schiffs bases of 3-{[2-({(E)-[substituted) phenyl] methylidene} amino) ethyl] amino} quinoxalin-2(1H)-one and evaluated for in vivo anticonvulsant activity. All the compounds were characterized by IR, 1H NMR data. This activity was carried out on pentylenetetrazole-induced seizure model. Compounds (IIIb) and (IIIc) Showed maximum time for straub tail and clonic convulsions. That means they possess good activity compared with standard. Animals treated with compounds (IIIb) and (IIIe) were recovered from this activity.

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Author Biography

Ratnadeep V. Ghadage, Department of Pharmaceutical Chemistry, Appasaheb Birnale College of Pharmacy, South Shivaji Nagar, Sangli 416416

Reasech student

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Published

2011-11-13

How to Cite

Ghadage, R. V., and P. J. Shirote. “Synthesis and Anticonvulsant Activity of Schiff’s Bases of 3-{[2-({(E)-[(substituted) Phenyl] Methylidene} Amino) Ethyl] Amino} Quinoxalin-2(1H)-One”. Bangladesh Journal of Pharmacology, vol. 6, no. 2, Nov. 2011, pp. 92-99, doi:10.3329/bjp.v6i2.8671.

Issue

Vol. 6 No. 2 (2011)

Section

Research Articles

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