Neuroprotective effect of juglone against 6-OHDA-induced neurotoxicity in PC12 cells

Authors

  • Qingqing Liu Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Collaborative Innovation Center of Life and Health, Hainan University, Haikou, 570228, China. https://orcid.org/0000-0002-4661-5794
  • Jiaolin Bao Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Collaborative Innovation Center of Life and Health, Hainan University, Haikou, 570228, China. https://orcid.org/0000-0003-0630-071X
  • Ren-bo Ding Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Collaborative Innovation Center of Life and Health, Hainan University, Haikou, 570228, China. https://orcid.org/0000-0003-0057-4488

DOI:

https://doi.org/10.3329/bjp.v21i1.87252

Keywords:

Apoptosis, Juglone, Neuroprotection, 6-OHDA, Oxidative stress, Parkinson’s disease

Abstract

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References

Andersen JK. Oxidative stress in neurodegeneration: Cause or consequence?. Nat Med. 2004; 10(Suppl 7): S18-25.

Chen L, Chang Y, Zhang S, Wang Z, Liu H, Wang H, Shi L, Li N, Feng S. Juglone promotes spinal cord injury recovery by suppressing pyroptosis and necroptosis through FOS/USP53/ubiquitination. Phytomedicine 2025: 148: 157341.

Cragg GM, Pezzuto JM. Natural products as a vital source for the discovery of cancer chemotherapeutic and chemopreventive agents. Med Princ Pract. 2016; 25: 41-59.

Kung HC, Lin KJ, Kung CT, Lin TK. Oxidative stress, mitochondrial dysfunction, and neuroprotection of polyphenols with respect to resveratrol in Parkinson's disease. Biomedicines 2021; 9: 918.

Li ZH, Zhang ZQ, Yu B. Unlocking the therapeutic potential of natural products for Alzheimer's disease. J Med Chem. 2025; 68: 2377-402.

Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 2006; 443: 787-95.

Newman DJ, Cragg GM. Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019. J Nat Prod. 2020; 83: 770-803.

Osztie R, Czegledi T, Ross S, Stipsicz B, Kalydi E, Beni S, Boldizsar I, Riethmueller E, Bosze SE, Alberti A. Comprehensive characterization of phytochemical composition, membrane permeability, and antiproliferative activity of Juglans nigra polyphenols. Int J Mol Sci, 2024; 25: 6930.

Tang YT, Li Y, Chu P, Ma XD, Tang ZY, Sun ZL. Molecular biological mechanism of action in cancer therapies: Juglone and its derivatives, the future of development. Biomed Pharmacother. 2022; 148: 112785.

Tolosa E, Garrido A, Scholz SW, Poewe W. Challenges in the diagnosis of Parkinson's disease. Lancet Neurol. 2021; 20: 385-97.

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Published

2026-03-02

How to Cite

Liu, Qingqing, et al. “Neuroprotective Effect of Juglone Against 6-OHDA-Induced Neurotoxicity in PC12 Cells”. Bangladesh Journal of Pharmacology, vol. 21, no. 1, Mar. 2026, pp. 35-38, doi:10.3329/bjp.v21i1.87252.

Issue

Vol. 21 No. 1 (2026)

Section

Letter to the Editor

License

Copyright (c) 2026 Qingqing Liu, Jiaolin Bao, Ren-bo Ding

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