In vitro and in vivo anti-inflammatory activity of leaves of Symplocos cochinchinensis (Lour) Moore ssp laurina
DOI:
https://doi.org/10.3329/bjp.v3i2.956Keywords:
Anti-inflammatory activity, Carrageenan, Symplocos cochinchinensisAbstract
The anti-inflammatory activities of different extracts of leaves Symplocos cochinchinensis Lour ssp laurina (Symplococaceae) were investigated for in vitro anti-inflammatory activity by human red blood cell membrane stabilization method. The methanol extract showed effective in vitro anti-inflammatory activity was screened for in vivo antiinflammatory activity by carrageenan-induced paw edema in rat model. The potency of the extracts was compared with standard diclofenac (50 mg/kg). The methanol extract showed significant membrane stabilizing action on human red blood cell membrane and reduction of edema in carrageenan induced rat paw edema model.
Downloads
214
293 Read
2
References
Ali M, Bhutani KK, Srivastava TN. Triterpenoids from Symplocos racemosa bark. Phytochemistry 1990; 29: 3601-04.
Ahmad VU, Abbasi MA, Hussain H, Akhtar MN, Farooq U, Choudhary MI. Phenolic glycoside from Symplocos racemosa natural inhibitors of phosphodiesterase I. Phytochemistry 2003; 63: 217-20.
Chou CT. The anti-inflammatory effect of Tripterygium wilfordii Hook F on adjuvant-induced paw edema in rats and inflammatory mediators release. Phytother Res. 1997; 11: 152-54.
Ecobichon DJ. The basis of toxicology testing. 2nd ed. New York, CRC Press, 1997, pp 43-60.
Gandhisan R, Thamaraichelvan A, Baburaj. Anti-inflammatory action of Lannea coromandelica Hrbc membrane stabilization. Fitotherapia 1991; 62: 82-83.
Ishida J, Wang HK, Oyama M, Cosentino ML, Hu CQ, Lee KH. Anti-AIDS agent. 46 Anti HIV activity of Harman and anti-HIV principle from Symplocos setchuensis and its derivatives. J Nat Prod. 2001; 64: 958-60.
Iwueke AV, Nwodo OF, Okoli CO. Evaluation of the anti-inflammatory and analgesic activities of Vitex doinana leaves. African J Biotech. 2006; 5: 1929-35.
Li XH Shen DD, Li N, Yu SS. Bioactive terpenoids from Symplocs chinensis. A. Asian Nat Prod Res. 2003; 5: 49-56.
Murugasan N, Vember S, Damodharan C. Studies on erythrocyte membrane IV: In vitro hemolytic activity of oleander extract. Toxicol Lett. 1981; 8: 33-38.
Vane JR, Botting RM. New insight into the mode of action of anti-inflammatory drugs. Inflamm Res. 1995; 44: 1-10.
Winter CA, Risley EA, Nuss GW. Carrageenan-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs. Proc Soc Expt Biol Med. 1962; 111: 44-47.
Additional Files
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
