In vitro and in vivo anti-inflammatory activity of leaves of Symplocos cochinchinensis (Lour) Moore ssp laurina

Authors

  • Rajendran Vadivu Department of Pharmacognosy, Madras Medical College, Chennai 03
  • K. S. Lakshmi Department of Pharmacognosy, S. R. M. College of Pharmacy, Chennai, Tamilnadu

DOI:

https://doi.org/10.3329/bjp.v3i2.956

Keywords:

Anti-inflammatory activity, Carrageenan, Symplocos cochinchinensis

Abstract

The anti-inflammatory activities of different extracts of leaves Symplocos cochinchinensis Lour ssp laurina (Symplococaceae) were investigated for in vitro anti-inflammatory activity by human red blood cell membrane stabilization method. The methanol extract showed effective in vitro anti-inflammatory activity was screened for in vivo antiinflammatory activity by carrageenan-induced paw edema in rat model. The potency of the extracts was compared with standard diclofenac (50 mg/kg). The methanol extract showed significant membrane stabilizing action on human red blood cell membrane and reduction of edema in carrageenan induced rat paw edema model.

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Author Biography

Rajendran Vadivu, Department of Pharmacognosy, Madras Medical College, Chennai 03

Lecturer

References

Ali M, Bhutani KK, Srivastava TN. Triterpenoids from Symplocos racemosa bark. Phytochemistry 1990; 29: 3601-04.

Ahmad VU, Abbasi MA, Hussain H, Akhtar MN, Farooq U, Choudhary MI. Phenolic glycoside from Symplocos racemosa natural inhibitors of phosphodiesterase I. Phytochemistry 2003; 63: 217-20.

Chou CT. The anti-inflammatory effect of Tripterygium wilfordii Hook F on adjuvant-induced paw edema in rats and inflammatory mediators release. Phytother Res. 1997; 11: 152-54.

Ecobichon DJ. The basis of toxicology testing. 2nd ed. New York, CRC Press, 1997, pp 43-60.

Gandhisan R, Thamaraichelvan A, Baburaj. Anti-inflammatory action of Lannea coromandelica Hrbc membrane stabilization. Fitotherapia 1991; 62: 82-83.

Ishida J, Wang HK, Oyama M, Cosentino ML, Hu CQ, Lee KH. Anti-AIDS agent. 46 Anti HIV activity of Harman and anti-HIV principle from Symplocos setchuensis and its derivatives. J Nat Prod. 2001; 64: 958-60.

Iwueke AV, Nwodo OF, Okoli CO. Evaluation of the anti-inflammatory and analgesic activities of Vitex doinana leaves. African J Biotech. 2006; 5: 1929-35.

Li XH Shen DD, Li N, Yu SS. Bioactive terpenoids from Symplocs chinensis. A. Asian Nat Prod Res. 2003; 5: 49-56.

Murugasan N, Vember S, Damodharan C. Studies on erythrocyte membrane IV: In vitro hemolytic activity of oleander extract. Toxicol Lett. 1981; 8: 33-38.

Vane JR, Botting RM. New insight into the mode of action of anti-inflammatory drugs. Inflamm Res. 1995; 44: 1-10.

Winter CA, Risley EA, Nuss GW. Carrageenan-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs. Proc Soc Expt Biol Med. 1962; 111: 44-47.

Additional Files

Published

2008-08-01

How to Cite

Vadivu, R., and K. S. Lakshmi. “In Vitro and in Vivo Anti-Inflammatory Activity of Leaves of Symplocos Cochinchinensis (Lour) Moore Ssp Laurina”. Bangladesh Journal of Pharmacology, vol. 3, no. 2, Aug. 2008, pp. 121-4, doi:10.3329/bjp.v3i2.956.

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Section

Research Articles