Synergistic activity of methanolic extract of Thespesia populnea (malvaceae) flowers with oxytetracycline

Authors

  • Arthanari Saravana Kumar Department of Pharmaceutical Biotechnology, Nandha College of Pharmacy, Erode 52, Tamilnadu
  • K. Venkateshwaran Department of Pharmaceutical Biotechnology, Nandha College of Pharmacy, Erode 52, Tamilnadu
  • J. Vanitha Department of Pharmaceutical Analysis, The Erode College of Pharmacy, Erode 112, Tamilnadu
  • V.S. Saravanan Department of Pharmaceutical Analysis, The Erode College of Pharmacy, Erode 112, Tamilnadu
  • M. Ganesh Department of Pharmaceutical Biotechnology, Nandha College of Pharmacy, Erode 52, Tamilnadu
  • M. Vasudevan Department of Pharmaceutical Biotechnology, Nandha College of Pharmacy, Erode 52, Tamilnadu
  • T. Sivakumar Department of Pharmaceutical Biotechnology, Nandha College of Pharmacy, Erode 52, Tamilnadu

DOI:

https://doi.org/10.3329/bjp.v4i1.958

Keywords:

Methanolic extract, Oxytetracycline, Synergistic activity, Thespesia populnea

Abstract

The object of this study was to formulate new, cost effective anti-microbial combination for multidrug resistant diseases based on the synergistic activity of oxytetracycline with methanolic extract of Thespesia populnea (Malvaceae) a medicinal plant common in South India. The MIC of methanolic extracts in combination with oxytetracycline using 12 different both gram positive and gram negative bacteria was found to be around (62.5 µg/mL to 1000 µg/mL). The synergistic activity was verified using Kirby and Bauer techniques. 83.3% shows synergistic activity against all 12 different bacteria both gram positive and gram negative species. The highest synergism rate was attained against Shigella boydii (ATCC8700).

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Published

2008-08-06

How to Cite

Kumar, A. S., K. Venkateshwaran, J. Vanitha, V. Saravanan, M. Ganesh, M. Vasudevan, and T. Sivakumar. “Synergistic Activity of Methanolic Extract of Thespesia Populnea (malvaceae) Flowers With Oxytetracycline”. Bangladesh Journal of Pharmacology, vol. 4, no. 1, Aug. 2008, pp. 13-16, doi:10.3329/bjp.v4i1.958.

Issue

Vol. 4 No. 1 (2009)

Section

Research Articles

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