@article{Zhou_Wang_Lin_Wang_Hou_2021, title={Bufalin inhibits the growth and epithelial to mesenchymal transition of human gastric cancer cells via modulation of MEK/ERK pathway}, volume={16}, url={https://banglajol.info/index.php/BJP/article/view/50548}, DOI={10.3329/bjp.v16i1.50548}, abstractNote={<p>This study was designed to evaluate the anti-cancer effects of bufalin against the human gastric cancer cells and unveil the underlying mechanism. The results showed that bufalin inhibited the proliferation and colony formation of the MGC-803 gastric cancer cells and exhibited an IC<sub>50</sub> of 10 μM. These antiproliferative effects were found to be due to the induction of G<sub>2</sub>/M cell cycle arrest. The G<sub>2</sub>/M cell cycle arrest was also concomitant with inhibition of cdc2, cdc25 and cyclin B1. Furthermore, bufalin suppressed the epithelial-to-mesenchymal transition, migration, and invasion of the MGC-803 gastric cancer cells. The Western blot analysis revealed that bufalin exerted its effects via deactivation of EK/ERK signaling pathway. Taken together, these results suggest the potential of bufalin as the lead molecule for the development of chemotherapy for gastric cancer.  </p>}, number={1}, journal={Bangladesh Journal of Pharmacology}, author={Zhou, Yi and Wang, Liguo and Lin, Hui and Wang, Yunxia and Hou, Kezhu}, year={2021}, month={Jan.}, pages={27–33} }