Bangladesh Journal of Pharmacology 2021-04-11T13:25:49+00:00 Mir Misbahuddin Open Journal Systems <p>Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, single blinded peer-reviewed journal of the&nbsp;Bangladesh Pharmacological Society&nbsp;(BDPS). We publish Research article, Mini-review, Meta-analysis, Clinical Trial, Visual Experiment and Letter to the Editor.&nbsp;<br> The author&nbsp;will not be charged in the form of submission fee, article processing fee or publication fee. It is completely free. We do not publish any advertisement.</p> <p><strong>Journal Metrics</strong><br> Journal metrics allow you to compare journals, regardless of their subject classification.<br>Impact Factor<sup>®</sup>&nbsp;as reported in the 2019 Journal Citation Reports<sup>®</sup>&nbsp;(Clarivate Analytics, 2020): <strong>1.306</strong></p> <p><img src="/public/site/images/misbah/IF1.png"></p> <p>CiteScore (2020):&nbsp;<strong>2.6</strong>&nbsp;&nbsp;<a href="">Current month's CiteScore Tracker</a><br> H index (2019): <strong>21</strong></p> <p>We have more than 10,000 readers from South Korea to Nigeria.</p> <p><strong>Abstracted/Indexed in</strong><br>Academic Search Complete, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts,&nbsp;<a href="">Directory of Open Access Journals</a>, EMBASE/Excerpta Medica, Global Health, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate,&nbsp;Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index</p> <p><strong>Members</strong><br>Bangladesh Journal of Pharmacology is the member of&nbsp;<a href="">OASPA</a>&nbsp;(Open Access Scholarly Publishers Association),&nbsp;<a href="">COPE</a>&nbsp;(Committee on Publication Ethics), The International Society of Managing and Technical Editors (<a href="">ISMTE</a>) and Asian Council of Science Editors.</p> <h1 style="color: red;">Our activities are slow due to COVID-19 Lockdown</h1> Wound healing properties of the protein kinase A inhibitor and the mechanisms of their development 2021-04-02T01:52:07+00:00 Gleb N. Zyuz`kov Larisa A. Miroshnichenko Tatyana Yu Polyakova Larisa A. Stavrova Elena V. Simanina <p>The regenerative activity of the protein kinase A inhibitor was investigated using externally on the model of the flap skin wound. The pronounced wound healing effects of the protein kinase A inhibitor had been revealed. They are based on the activation of mesenchymal progenitor cells. The development of this phenomenon was associated with the direct influence of the protein kinase A inhibitor on mesenchymal progenitor cells. The most significant stimulation of their growth potential occurred in the context of the impact of growth factors in particular fibroblast growth factor secreted by the stromal cells. Moreover, <em>in situ</em>, there was an increase not only in proliferating activity but also in the intensity of the specialization processes of progenitors. Without cytokines stimulation, the change in the pattern of cellular cAMP-mediated signal does not affect the maturation rate of precursors.</p> 2021-04-01T05:36:10+00:00 ##submission.copyrightStatement## Effects of paeonol on proliferation and collagen synthesis of rat cardiac fibroblasts induced by aldosterone 2021-04-02T13:25:30+00:00 Qian Xu Li Na Wang Jing Yi Zhao Yan Hong Xiao Chao Du <p>The aim of this study was to explore the possible molecular mechanisms of paeonol in preventing ventricular remodeling. The cell viability of neonatal rat cardiac fibroblasts was detected by the method of MTT. RT-PCR and Western blot were used to measure the expression of TGF-β1, type I collagen and type III collagen. After treating the cardiac fibroblasts with paeonol, the cell viability decreased (p&lt;0.01), and the expression of TGF-β1, type I collagen and types III collagen was significantly reduced (p&lt;0.01). Thus, paeonol can inhibit the proliferation of fibroblast cells induced by aldosterone. The molecular mechanism is related to the down-regulation of TGF-β<sub>1</sub> and type I and III collagen gene expression.</p> 2021-04-02T00:00:00+00:00 ##submission.copyrightStatement## Tongxinluo preserves the renal function in diabetic kidney disease via protecting the HK-2 cells from the patterns of programmed cell death 2021-04-11T13:25:49+00:00 Shuang Shen Yunlong Hou Yiling Wu <p>This study was explored the renoprotective effect of Tongxinluo (a Traditional Chinese Medicine) on diabetic kidney disease and its underlying mechanism. The results revealed significant (p&lt;0.05) up-regulation of the expression of Bcl-2 and down-regulation of NF-κB p-p65, ASC, NLRP3, caspase-1, cleaved GSDMD, IL-1β, caspase-3, Bax and the ratio of Bcl-2 and Bax in immortalized proximal tubular HK-2 cells cultured by hyperglycemia combined with hyperlipidemia. In db/db mice, Tongxinluo treatment substantially decreased the 24 hours albuminuria excretion rate and the urine albumin-creatinine ratios and renal morphologic abnormalities. Similarly, the levels of NF-κB p-p65, NLRP3, caspase-1, cleaved GSDMD, IL-1β, caspase-3, and the ratio of Bcl-2 and Bax were down-regulated by Tongxinluo treatment in the kidney samples of db/db mice (p&lt;0.05). Taken together, according to the anti-pyroptosis and anti-apoptosis effect of Tongxinluo, it shows the potential to be effective for the treatment of diabetic kidney disease.</p> 2021-04-11T05:35:16+00:00 ##submission.copyrightStatement## Antibacterial activity of an ornamental plant Hippeastrum fosteri 2021-04-08T13:25:43+00:00 Gayathri Segaran Mythili Sathiavelu 2021-04-08T02:44:25+00:00 ##submission.copyrightStatement##