Study on expression of cytokine genes in peripheral blood mononuclear cells (PBMCs) following Hepatitis B vaccination

Authors

  • Marufa Hossain Assistant Professor of Microbiology, Z.H. Sikder Women?s Medical College, Dhaka
  • Omma Hafsa Any Assistant Professor of Pharmacology, Z.H. Sikder Women?s Medical College, Dhaka
  • Rezina Sultana Assistant Professor of Pharmacology, Z.H. Sikder Women?s Medical College, Dhaka
  • Farjana Majid Assistant Professor of Microbiology, Tairunnessa memorial Medical College, Gazipur, Dhaka
  • Nashid Tabassum Khan Assistant Professor of Forensic Medicine, Z.H. Sikder Women?s Medical College, Dhaka

DOI:

https://doi.org/10.3329/bjpp.v29i1-2.20064

Keywords:

Hepatitis B vaccine, RT-PCR, INF-?, Cytokine, Gene

Abstract

Vaccination with surface protein of Hepatitis B Virus (HBsAg) is considered the main strategy for effective control of the infection and viral transmission. The present study was designed to determine the expression of Interferon (INF-?) in peripheral blood mononuclear cells (PBMCs) by RT-PCR method. In the present study, PBMCs from responders expressed INF-? gene in response to HBsAg, while nonresponders expressed low levels of this cytokines. Most humoral non responders to HBV thus develop specific cellular immune responses, eventually liable to protect them against viral infection.

http://dx.doi.org/10.3329/bjpp.v29i1-2.20064
Bangladesh J Physiol Pharmacol 2013; 29(1&2) : 25-28

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Published

2014-08-18

How to Cite

Hossain, M., Any, O. H., Sultana, R., Majid, F., & Khan, N. T. (2014). Study on expression of cytokine genes in peripheral blood mononuclear cells (PBMCs) following Hepatitis B vaccination. Bangladesh Journal of Physiology and Pharmacology, 29(1-2), 25–28. https://doi.org/10.3329/bjpp.v29i1-2.20064

Issue

Vol. 29 No. 1-2 (2013)

Section

Original Articles