Comparison between Antioxidant Effect of Vitamin-C Alone and its Combination to Vitamin-E in Long Evans Norwegian Rat

Authors

  • Mohammed Ikram Ullah Khan Professor (CC), Department of Pharmacology, BGC Trust Medical College, Chittagong
  • Selim Mohammed Jahangir Associate Professor, Department of Pharmacology, Chittagong Medical College, Chittagong
  • Syeda Razia Karim Department of Gynae & Obs., Chittagong Medical College Hospital
  • AKM Nurul Anwar Professor of Pharmacology and Principal, Ibrahim Medical College, Dhaka

DOI:

https://doi.org/10.3329/bjpp.v23i1.5726

Keywords:

Vitamin C, vitamin E, antioxidant

Abstract

In rat myocardial damage was produced the administration of adrenaline in a dose of 2 mg/kg body weight (b.w.) subcutaneously for 2 consecutive mornings. This damage was assessed indirectly by significant increase in serum aspertate transminase (AST) and directly by microscopic changes in the myocardium.

Pretreatment with the vitamin-C in a dose 10mg/kg body weight subcutaneously and preteatment with the combination of vitamin-C in a dose of 10mg/kg b.w. subcutaneously and vitamin-E in a dose of 50mg/kg b.w. orally for 10 days prevented the adrenaline induced myocadial damage equally which was evidenced by the equal prevention in the rise of serum AST & LDH levels as well as equal prevention of microscopic changes of the myocardium by the adrenaline.

DOI: 10.3329/bjpp.v23i1.5726

Bangladesh J Physiol Pharmacol 2007; 23(1&2) : 16-19

Downloads

Download data is not yet available.
Abstract
618
PDF
868

Downloads

How to Cite

Khan, M. I. U., Jahangir, S. M., Karim, S. R., & Anwar, A. N. (2010). Comparison between Antioxidant Effect of Vitamin-C Alone and its Combination to Vitamin-E in Long Evans Norwegian Rat. Bangladesh Journal of Physiology and Pharmacology, 23(1), 16–19. https://doi.org/10.3329/bjpp.v23i1.5726

Issue

Section

Original Articles