Cytotoxic Activity of Two Limonoids Isolated From <i>Swietenia mahagoni</i> by Using Brine Shrimp Lethality Bioassay

Authors

  • AKM Shahidur Rahman Department of Pharmacology and Therapeutics, Khwaja Yunus Ali Medical College, Enayetpur Sharif, Post- Enyetpur, Sirajgonj
  • AK Azad Chowdhury Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Hossain Reza Department of Physiology, Khwaja Yunus Ali Medical College, Enayetpur Sharif, Post- Enyetpur, Sirajgonj
  • Mohammad Shawkat Ali Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Manzurur Rahman Shah Choudhury Department of Physiology, Khwaja Yunus Ali Medical College, Enayetpur Sharif, Post- Enyetpur, Sirajgonj
  • Lutfun Nahar School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, Co. Londonderry, Northern Ireland
  • Satyajit D Sarker School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, Co. Londonderry, Northern Ireland

DOI:

https://doi.org/10.3329/bjpp.v24i1.5729

Keywords:

Cytotoxic, Limonoid, Swietenia mahagoni, Brine shrimp lethality bioassay

Abstract

Solvent partitioning followed by column chromatography of the MeOH extract of the seeds of Swietenia mahagoni afforded two limonoids, swietenolide (compound 1) and 2-hydroxy-3-O-tigloylswietenolide (compound 2), later one is new compound. The compounds were identified by spectroscopic means. The cytotoxic activity of these compounds was assessed by using the conventional brine shrimp lethality bioassay. While both compounds were found to have moderate cytotoxic activity, compound 2 displayed overall more potent activity than compound 1.

Key words: Cytotoxic; Limonoid; Swietenia mahagoni; Brine shrimp lethality bioassay

DOI: 10.3329/bjpp.v24i1.5729

Bangladesh J Physiol Pharmacol
2008; 24(1&2) : 1-6

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How to Cite

Rahman, A. S., Chowdhury, A. A., Reza, H., Ali, M. S., Choudhury, M. R. S., Nahar, L., & Sarker, S. D. (2010). Cytotoxic Activity of Two Limonoids Isolated From <i>Swietenia mahagoni</i> by Using Brine Shrimp Lethality Bioassay. Bangladesh Journal of Physiology and Pharmacology, 24(1), 1–6. https://doi.org/10.3329/bjpp.v24i1.5729

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