A Randomized Controlled Trial of Misoprostol and Oxytocin in the Management of Third Stage of Labor

Authors

  • Rokshana Ivy Senior Consultant, Department of Obstetrics & Gynecology, Maternal and Child Health Training Institute, Azimpur, Dhaka
  • Hasmot Ara Medical Officer, Department of Obstetrics & Gynecology, Maternal and Child Health Training Institute, Azimpur, Dhaka
  • Kulsum Haq Assistant Professor, Department of Obstetrics & Gynecology, Begum Khaleda Zia Medical College, Dhaka
  • Farid Uddin Ahmed Deputy Program Manager, Directorate General of Family Planning, Dhaka

DOI:

https://doi.org/10.3329/bjpp.v24i1.5732

Keywords:

Misoprostol, Oxytocin, Postpartum haemorrhage

Abstract

The study was conducted to compare the effectiveness and safety of oral misoprostol with intramuscular oxytocin in the management of third stage of labor. One hundred patients were selected randomly who are expected to have vaginal delivery. Fifty patients received oral misoprostol 600 microgram and other fifty patients received oxytocin 10 IU intramuscularly after the birth of the baby. There were no significant differences between the prevalence of postpartum hemorrhage, duration of third stage of labor, additional oxytocin requirement, manual removal of placenta and blood transfusion. About the side-effects, shivering and fever were significantly higher in misoprostol group (p<0.001) and (p<0.003) respectively. But there were no significant differences in other sideeffects. Oral misoprostol can be used instead of intramuscular oxytocin in the management of third stage of labor, to prevent postpartum hemorrhage, in developing countries, especially as it is administered orally and thermo stable in tropical climate.

Key words: Misoprostol; Oxytocin; Postpartum haemorrhage

DOI: 10.3329/bjpp.v24i1.5732

Bangladesh J Physiol Pharmacol 2008; 24(1&2) : 14-16

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How to Cite

Ivy, R., Ara, H., Haq, K., & Ahmed, F. U. (2010). A Randomized Controlled Trial of Misoprostol and Oxytocin in the Management of Third Stage of Labor. Bangladesh Journal of Physiology and Pharmacology, 24(1), 14–16. https://doi.org/10.3329/bjpp.v24i1.5732

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Original Articles