Drug-Induced Gingival Overgrowth - A Review

Authors

  • Mst Fatema Akhter Lecturer of Oral Anatomy and Physiology, Pioneer Dental College
  • Shaheen Lipika Quayum Assistant Professor of Pharmacology, Pioneer Dental College
  • Afrin Bintal Ali Assistant Professor of Public health, Pioneer Dental College
  • Zia Mamoon Assistant Professor of Preventive Dentistry, Pioneer Dental College

DOI:

https://doi.org/10.3329/bjpp.v25i1.5743

Keywords:

Gingival overgrowth

Abstract

Drug-induced gingival overgrowth is a side effect associated with 3 types of drugs: anticonvulsants (phenytoin), immunosuppressive agents (cyclosporine A), and various calcium channel blockers for cardiovascular diseases. Gingival overgrowth is characterized by the accumulation of extracellular matrix in gingival connective tissues, particularly collagenous components with various degrees of inflammation. Although the mechanisms of these disorders have not been elucidated, recent studies suggest that these disorders seem to be induced by the disruption of homeostasis of collagen synthesis and degradation in gingival connective tissue, predominantly through the inhibition of collagen phagocytosis of gingival fibroblasts. In this review, we focus on collagen metabolism in drug-induced gingival overgrowth, focusing on the regulation of collagen phagocytosis in fibroblasts.

DOI: 10.3329/bjpp.v25i1.5743

Bangladesh J Physiol Pharmacol 2009; 25(1&2) : 26-29

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How to Cite

Akhter, M. F., Quayum, S. L., Ali, A. B., & Mamoon, Z. (2010). Drug-Induced Gingival Overgrowth - A Review. Bangladesh Journal of Physiology and Pharmacology, 25(1), 26–29. https://doi.org/10.3329/bjpp.v25i1.5743

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Section

Review Articles