Intervention Trial of Microalbuminuria in T2DM with Antioxidant, Antithrombotic and ACE Inhibitor Agents

Abstract

The present study was undertaken in T2DM patients aged between 40 and 50 years, from outpatient department (OPD) of BIRDEM Hospital, Shahabagh, Dhaka.

A total of 1605 T2DM patients examined, 390 were found microalbominuric (ì-albumin >30mg/g) giving a prevalence rate were 22.92%. and nonmicroalbuminuric (ì-albumin d"30 mg/g). The microalbuminuric subjects were put on intensive intervention with ACE inhibitor (Captopril 25 mg, twice daily), Antioxidant (Vitamin C- 200 mg, Vitamin E- 50 mg and Vitamin A- 6 mg daily), and Antithrombotic (Aspirin- 75 mg daily). Both microalbuminuric and nonmicroalbuminuric subjects were put on strict diet control and antidiabetic therapy. The following tests FBG, HbA1c, BP, T-Cholesterol, HDLc, ì-albumin, ACR, were done in both groups at 3 months intervals up to 18th months.

The mean (years) ±SD age were 45.67 ± 3.98, and 45.45 ±3.94 and duration of diabetes 3.78 ± 3.14 and 3.72±3.07 in microalbuminuric and nonmicroalbuminuric subjects respectively. The microalbuninuric group showed satistically significant difference (p<0.005) in the following parameters FBG, HbA1c, SBP, T-choles, ACR, U.Creatinine in comparison to nonmicroalbuminuric group.

Nonmicroalbuminuric subjects showed the deterioration in TG, HDLc, and a conversion rate of 21.7% from nonmicroalbuminuric to microalbuminuric.

The present intervention with ACE inhibitor, antioxidant and antithrombotic improved glycaemic control, lipid profile and renal functions by 68% in microalbuminuric T2DM subjects.  

DOI: 10.3329/bmj.v37i2.3589

Bangladesh Medical Journal 37(2) 2008 30-36