@article{Khaleda_Al-Forkan_Wali_Alam_Datta_Shawon_Hosain_Rahman_2019, title={Effect of arsenic exposure on human telomerase reverse transcriptase (hTERT) gene expression: Risk of cardiovascular diseases: Arsenic exposure and cardiovascular diseases}, volume={45}, url={https://banglajol.info/index.php/BMRCB/article/view/41802}, DOI={10.3329/bmrcb.v45i1.41802}, abstractNote={<p><strong>Background:</strong> Exposure to inorganic arsenic (iAs) through drinking water is currently a serious threat to public health of millions of people worldwide including Bangladesh. Some recent studies have shown that telomere dysfunction is emerging as an important factor in the pathogenesis of different cardiovascular diseases. Arsenic plays significant role on telomere dysfunction by altering the expression of telomere-related genes.</p> <p><strong>Objective: </strong>The study was aimed to investigate the effects of arsenic on <em>hTERT</em> mRNA levels and their combined role in increasing CVD susceptibility.</p> <p><strong>Methods: </strong>In this cross sectional study, total of 50 CVD patients who underwent open heart surgery were recruited. Urine, nail and cardiac tissue samples were collected and analysed for As. Blood samples were quantified for <em>hTERT</em> expression analysis using real-time polymerase chain reaction.</p> <p><strong>Results: </strong>The <em>hTERT </em>mRNA expression was found approximately 10 fold higher in the As-exposed patients than the As-unexposed patients (<em>p</em><0.01). A strong positive correlation (<em>p</em><0.01, r>0.3) was found between the <em>hTERT</em> mRNA levels and As contents in the cardiac tissue, nail and urine samples of the study subjects. The significant increase (approx. 4 fold) in the <em>hTERT</em> mRNA expression was found in the patients with coronary artery disease (CAD) than the non-CAD patients.</p> <p><strong>Conclusions: </strong>The results of the study suggest that arsenic exposure increases <em>hTERT</em> mRNA expression which may in turn modify As-induced cardiovascular outcomes. The findings of this study will help to look deep into the association of As exposure in cardiovascular disease pathogenesis to open a new window in the diagnosis and treatment procedure of CVD.</p> <p>Bangladesh Med Res Counc Bull 2019; 45: 03-10</p>}, number={1}, journal={Bangladesh Medical Research Council Bulletin}, author={Khaleda, Laila and Al-Forkan, Mohammad and Wali, Fahmida Binta and Alam, Md Jibran and Datta, Amit and Shawon, Inzamamul Ismail and Hosain, Nazmul and Rahman, Md Zillur}, year={2019}, month={Jun.}, pages={3–10} }