@article{Barua_Barua_Barua_Barua_Ansari_Chong_Uozaki_Fukayama_2019, title={Tumor necrosis factor-α polymorphism in helicobacter pylori associated gastric carcinoma}, volume={45}, url={https://banglajol.info/index.php/BMRCB/article/view/44647}, DOI={10.3329/bmrcb.v45i3.44647}, abstractNote={<p><em>Background:</em> Gastric cancer (GC) is the leading cause of cancer death in the world. Chronic inflammation is a predisposing factor of gastric carcinogenesis. TNF-α is a key pro-inflammatory cytokine secreted by macrophages and causes development of malignant diseases. It also plays an important role in chronic inflammation caused by Helicobacter Pylori. Therefore, TNF-α polymorphisms is studied in Helicobacter Pylori infected gastric cancer.</p> <p><em>Objective:</em> To find out the high risk group of Helicobacter Pylori infected gastric cancer cases in Asian and Caucasian people.</p> <p><em>Methods: </em>A total of 130 GC cases and 103 healthy controls from Jichi Medical School, Japan were studied. TNF-α genotype and allele frequency were studied by Restriction Fragment Length Polymorphism (RFLP).</p> <p><em>Results: </em>Among the study population TNFa-308A was less frequent in Asian people than those of Caucasian. TNFa-238G allele was more frequent in H. pylori positive GC (<em>p</em><0.036) cases.</p> <p><em>Conclusion: </em>Findings of the study suggest that TNF-238G polymorphism of TNF-α gene may be closely associated with susceptibility to Helicobacter Pylori infected gastric cancer in Asian patients.  This might be due to high cytokine production by TNF-238G allele.</p>}, number={3}, journal={Bangladesh Medical Research Council Bulletin}, author={Barua, Rita Rani and Barua, Sushanta and Barua, Hena Rani and Barua, Ajoy Kishore and Ansari, M.A. Jalil and Chong, J-M and Uozaki, Hiroshi and Fukayama, Masashi}, year={2019}, month={Dec.}, pages={170–174} }