TY - JOUR AU - Hasan, Abu AU - Rahim, Rummana AU - Rahman, Mizanur PY - 2021/06/29 Y2 - 2024/03/28 TI - Alteration of biomarkers of expired and cured COVID- 19 ICU patients in a tertiary care hospital: Alteration of biomarkers of expired JF - Bioresearch Communications JA - Bioresearch Communications VL - 7 IS - 2 SE - Original Article DO - 10.3329/brc.v7i2.54378 UR - https://banglajol.info/index.php/BRC/article/view/54378 SP - 1031-1037 AB - <p>Coronavirus Disease 2019 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2). This is a retrospective observational study aimed to find the alteration of some biochemical and hematological parameters of 121 COVID-19 patients admitted in intensive care unit (ICU) of Evercare Hospital Dhaka during May to December 2020.</p><p><strong>Methods: </strong>Retrospective biochemical, hematological and molecular (COVID-19 RT-PCR Ct value) markers were analyzed on COVID-19 patients in ICU and compared on those who died in the ICU and those cured.</p><p><strong>Results: </strong>Comparison of viral titer assessed by RT-PCR Ct values of target genes of SARS-CoV-2 among cured and expired patients did not show any significant differences. However, biochemical parameters such as CRP, Ferritin and hematological parameters such as WBC, absolute neutrophil, absolute lymphocyte, D-dimer showed significant differences among cured and expired patients. Patients who died in ICU mean CRP, Ferritin, D-dimer, WBC, absolute neutrophil were 10.39, 7694.30, 3196, 16.38, 15.12 respectively, compared to cured patients 0.93, 457.57, 773, 11.24, 8.86 respectively, with 95% confidence interval (95% CI). Platelets and absolute lymphocytes were observed decreased in expired patients compared to cured. Further, elevated level of neutrophil to lymphocyte ratio (NLR) and reduced level of lymphocyte to C-reactive protein ratio (LCR) has significant correlation with disease severity.</p><p><strong>Conclusion: </strong>These findings indicate that biochemical parameters such as CRP, Ferritin and hematological parameters such as CBC, D-Dimer, NLR, LCR can be monitored to identify severity and fatality of COVID-19 patients and thus, may help in improving disease outcome.</p><p>Bioresearch Commu. 7(2): 1031-1037, 2021 (June)</p> ER -