Utility of Serum HE4 and CA-125 in Monitoring Chemotherapy Response During Neoadjuvant Chemotherapy in Advanced Epithelial Ovarian Carcinoma

Authors

  • Mst Rukshana Pervin Pervin Junior Consultant (Gynae and Obstetrics) Kurmitola General Hospital, Dhaka
  • Shahana Pervin Professor, Department of Gynaecological Oncology, National Institute of Cancer Research and Hospital (NICRH), Dhaka
  • Nizamul Haque Former Director, National Institute of Cancer Research and Hospital (NICRH), Dhaka
  • Jahirul Islam Associate Professor of Epidemilogy, National Institute of Cancer Research and Hospital (NICRH), Dhaka
  • Sufi Hannan Associate Professor, Immunology Department, National Institute of Cancer Research and Hospital (NICRH), Dhaka, Bangladesh
  • Rifat Ara Assistant Professor, Department of Gynaecological Oncology, National Institute of Cancer Research and Hospital (NICRH), Dhaka
  • Sadia Jabeen Khan Assistant Professor, Department of Gynaecological Oncology, National Institute of Cancer Research and Hospital (NICRH), Dhaka
  • Mohammad Abu Sayeed Talukder Assistant Professor (Curriculum Development), Centre for Medical Education (CME), Dhaka

DOI:

https://doi.org/10.3329/cmej.v4i2.84277

Keywords:

Advanced Epithelial Ovarian Carcinoma, Neoadjuvant Chemotherapy, Serum HE4 and CA-125.

Abstract

Background: In recent years the most fatal gynecological cancer is ovarian cancer (OC) and it is the eighth leading cause of cancer death in women. Neoadjuvant Chemotherapy (NACT) subsequently interval debulking surgery (IDS) is a substitute treatment approach in advanced epithelial ovarian cancer. Relapse associated with chemoresistance is shown in fifty to seventy percent of treated patients, which is one of the foremost challenges to deal with in ovarian cancer research.

Objectives: This survey was driven to evaluate the effectiveness of serum HE4 and CA-125 in monitoring the response of chemotherapy in advanced epithelial ovarian cancer who are selected for Neoadjuvant Chemotherapy (NACT).

Methods: This cross-sectional comparative study was conducted from January 2022 to December 2022 at the National Institute of Cancer Research and Hospital to find out the association of serum levels of HE4 and CA125 with the clinical and tomographic response after neoadjuvant chemotherapy in advanced ovarian carcinoma.

Results: Principal number of respondents were from the 41-50 years age group. The mean age of the patients were 52.27 (SD: ±10.55) years. In this current study association between response category and HE4 level after NACT is examined. The mean value of HE4 after NACT in no-response group was 539.03 whereas in response group this value decreased to

140.58. On independent t-test this difference was statistically significant (p=0.027). However, association between response category and CA-125 level after NACT was not statistically significant (p>0.05).

Conclusion: HE4 and CA-125 biomarkers can be effectively used to monitor the response of chemotherapy in advanced epithelial ovarian cancer who are selected for NACT, further study is needed to understand the impact of the biomarkers in terms of successful cytoreduction, in predicting platinum sensitivity, disease-free survival, risk to progress and overall survival.

CME J 2025; 4(2):49-61

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Published

2025-09-18

Issue

Vol. 4 No. 2 (2025)

Section

Original Article

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