Central Medical College Journal 2024-01-21T08:01:37+00:00 Professor Dr. Md. Mahabubul Islam Majumder Open Journal Systems <p>Published by Central Medical College, Cumilla<strong>. </strong>Full-text articles available.</p> <p><img class="alignright" src="" alt="image" width="88" height="31" /><br />Articles in the Central Medical College Journal are Open Access articles published under the Creative Commons CC BY-NC-ND License <span class="cc-license-title"><a href="" target="_blank" rel="noopener">Attribution-NonCommercial-NoDerivatives 4.0 International License.</a>This license permits <strong>Share</strong>— copy and redistribute the material in any medium or format.</span></p> Laser In Proctology 2024-01-03T05:17:40+00:00 Nasir Uddin Mahmud <p>Abstract not available&nbsp;</p> <p>Central Medical College Journal Vol 7 No 1 January 2023 Page: 3</p> 2024-01-21T00:00:00+00:00 Copyright (c) 2023 Central Medical College Journal From The Desk of Editor In Chief Vol. 7(1) 2024-01-03T05:07:28+00:00 Md Mahabubul Islam Majumder <p>Abstract not availabe </p> <p>Central Medical College Journal Vol 7 No 1 January 2023 Page: 02</p> 2024-01-21T00:00:00+00:00 Copyright (c) 2023 Central Medical College Journal Navigating Isolated Post-Traumatic Radial Head Dislocation in Adolescents: A Case Report from Bangladesh Emphasizing Management Strategies 2024-01-10T17:18:45+00:00 Kawser Hamid Mohammad Mainul Hasan <p><strong>Background: </strong>Isolated anterior dislocation of the radial head is a rare orthopedic injury, often<br />presenting with distinct clinical features and requiring specialized management. We report the case of an 18-year-old female who presented to our hospital 5 months post-injury, complaining of restricted left elbow joint movement and pain following a fall from a low chair at home. Clinical examination revealed tenderness and anterior dislocation of the radial head, confirmed by radiographs showing isolated anterior dislocation without associated fractures. Closed reduction attempts failed, leading to an open reduction of radial head in combination with correction of malignant with ulnar osteotomy and reconstruction of annular ligament and radio-ulnar Kirschner wire placement for stabilization. An upper arm cast was applied with the forearm in neutral rotation for six weeks. At the 12-month follow-up, the patient exhibited a satisfactory range of motion within reference values, comprising 0-140 degrees of flexion-extension arc, 70 degrees of pronation, and 85 degrees of supination. This range aligned with standards set by the American Society for Surgery of the Hand. The patient reported no impediments in daily activities and returned to her pre-injury level of sports activity based on the Tegner scale. This case underscores the complexity of managing isolated anterior radial head dislocation, highlighting the significance of prompt diagnosis, appropriate reduction techniques, and meticulous postoperative care to achieve optimal functional outcomes.</p> <p>Central Medical College Journal Vol 7 No 1 January 2023 Page: 57-62</p> 2024-01-21T00:00:00+00:00 Copyright (c) 2023 Central Medical College Journal Management of Giant Cell Tumor by Curettage and Bone graft in Weight Bearing Bone - A Study Done in CENTRAL MEDICAL COLLEGE. 2024-01-03T04:41:14+00:00 Md Kawser Hamid Md Mainul Hasan Md Arifur Rahaman Mohammad Emdadul Hoque Md Safiqur Rahman Patwary Minhazur Rahman <p><strong>Background: </strong>Giant cell tumor of bone (GCT) has been characterized as benign but often locally aggressive neoplasm that commonly occurs in proximity to weight bearing bone. Management of giant cell tumor of bone by curettage and bone graft in weight bearing bone is an effective method. This prospective experimental study was conducted among the patients with histologically proved giant-cell tumor who were admitted in the Department of orthopedic surgery, Central Medical College Hospital over a period of 18 months from January 2018 to June 2020. A total of 12 consecutive patients with histologically proved giant-cell tumour were included in the study. Majority (55.6%) of patient was in 3rd decade and male female ratio was 1:1.3. More than one fourth (25%) of the patients had GCT in the lower end of right femur, 33.3% in lower end of left femur, 25% in upper end of tibia, 16.7% in lower end of tibia and all patients had painful gait and swelling. According to campanacci grading, Grade-2 was found in all patients, and giant cell tumor was found in all patients, as evaluated by pre-operative biopsy. Cosmetically near normal appearance was found in 88.9% and 88.9% were able to do normal daily work. According to Schatzker and Lamber (1979) criteria excellent outcome was found in 41.7%, good in 50%, fair in 8.3%. Surgery in the form of intralesional curettage and filling the cavity with bone graft resulted in excellent relief of pain, cosmetically near normal appearance and patients were able to do normal daily work.</p> <p>Central Medical College Journal Vol 7 No 1 January 2023 Page: 7-12</p> 2024-01-21T00:00:00+00:00 Copyright (c) 2023 Central Medical College Journal Evaluation of effectiveness of Letrozole in treatment of infertility in women with polycystic ovary syndrome 2024-01-03T09:13:22+00:00 Jasrin Akter Mile Mashuma Munni Dilara Rahman Tahamina Parvin Shanaz Pervin <p><strong>Background</strong>: Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disease, characterized by hyperandrogenism, oligomenorrhea, and polycystic ovaries. PCOS is one of the most causes that affect the women of childbearing age, and often leads to infertility. Various managements were proposed for infertile women with PCOS. However, the optimal management option has not been addressed satisfied. Although multiple treatments including weight reduction, clomiphene citrate, metformin, gonadotropins, and ovary cauterization have been reported to treat such condition, the efficacy still has insufficient evidence to support.</p> <p><strong>Objectives</strong>: Purpose of this study was to evaluate the effectiveness of Letrozole in treatment of infertility in women with polycystic ovary syndrome.</p> <p><strong>Materials &amp; method:</strong> This study was carried out to assess the effectiveness of letrozole and on pregnancy outcomes including the ovulation induction, pregnancy rate, and endometrial thickness in infertile women with polycystic ovarian syndrome (PCOS). Total 106 infertile PCOS patients were recruited and allocated in two groups, Group-L (received letrozole at 2.5 mg twice daily on the 3rd–5th days of menstrual cycle for 5 consecutive days), Group-G 75 U/d−1 gonadotropin through intramuscular injection for 5 days starting from the third day of menstrual cycle). All patient in both arm completed treatment and follow-up. Patients in both groups were treated up to 5 treatment cycles. During follow up, transvaginalultrasonogram (TVS) was performed to see the details of the follicles and the endometrium. Data was processed and analysed with the help of computer program SPSS and Microsoft excel. Quantitative data expressed as mean and standard deviation and qualitative data as frequency and percentage. Comparison was done by tabulation and graphical presentation in the form of tables, pie chart, graphs, bar diagrams, histogram &amp; charts etc.</p> <p><strong>Result</strong>: Mean age of the patient was 26.3 ± 5.7 years in group-L and 25.9 ± 6.1 years in group-G. There were no statistical significant differences between the 2 groups regarding age, body weight, height, body mass index (BMI). Present study results showed that patients who received letrozole exert better outcomes in primary endpoint, including ovulation rate (86.7% in group-L &amp; 62.2% in group-G, P =0.004), endometrial thickness (9.3 ± 1.1 mm in group-L &amp; 8.5 ± 1.1 mm in group-G, P = 0.003) and pregnancy rate (64.1% in group-L &amp; 30.1% in group-G, P =0.005). Abortion rate (till the end of 12th week) and multiple pregnancy rate were higher in group-G, but result were non-significant in between groups. Live birth rate in the letrozole group was higher 29(54.7%) than group-G 14(26.4%), the difference was statistically significant (P &lt; .05).</p> <p><strong>Conclusion</strong>: Patients who took Letrozole had significantly higher endometrial thickness than other group. Due to the higher pregnancy rate and lower incidence of abortion or multiple pregnancy, letrozole can be an effective for the treatment of anovulatory subfertility of the PCOS patients. </p> <p>Central Medical College Journal Vol 7 No 1 January 2023 Page: 13-19</p> 2024-01-21T00:00:00+00:00 Copyright (c) 2023 Central Medical College Journal Premalignant and Malignant Esophageal Lesions in Bangladeshi Patients-A Study in a Tertiary Care Hospital 2024-01-10T14:28:47+00:00 Shifayat Sultana Rumana Afrin Sweety Mahbuba Zhumur Md Ariful Islam Fatima Tuj Jahra Rezaul Karim Dewan <p><strong>Background: </strong>In Bangladesh esophageal carcinoma is the leading malignant condition. Mortality rate of esophageal cancer is very high. Like other malignancies, early detection offers the best prognosis for esophageal carcinoma. Regular endoscopic and histologic surveillance have become standard procedure for follow up of patients with premalignant lesions.</p> <p><strong>Objectives:</strong> The aim of this study was to evaluate the frequency and pattern of esophageal lesions with respect to age and sex groups and to determine the trends of histology, site distribution and risk factors of it.</p> <p><strong>Methods: </strong>This study was a cross sectional study, carried out at the department of Pathology in Dhaka Medical College and Hospital from March 2018 to February 2020. Total 54 cases of esophageal biopsy were included in this study. All obtained samples were selected for routine histopathological study.</p> <p><strong>Results: </strong>Most of the patients were male and mean age was 55.04 (±15.48) years. Squamous cell carcinoma was the most common malignancy seen in (26 cases) 48.15 % of patients and Barrett’s esophagus was common (13 cases, 24.07%) premalignant lesion. Maximum malignant and premalignant lesions (40 cases, 74.07%) were located in lower thoracic region of esophagus including gastro esophageal junction. Dysphagia was the main presenting complain in 96.3% of patients and 55.6% of patients were smoker.</p> <p><strong>Conclusion: </strong>Barrett’s esophagus was the common premalignant lesion and squamous cell carcinoma was the commonest esophageal carcinoma followed by adenocarcinoma.</p> <p>Central Medical College Journal Vol 7 No 1 January 2023 Page: 20-25</p> 2024-01-21T00:00:00+00:00 Copyright (c) 2023 Central Medical College Journal Knowledge, Attitude and Exposure to Secondhand Smoking Among Women in Rural Setting 2024-01-10T15:08:06+00:00 Ayesha Mahzabin Chowdhury Fatema Akter Lima Md Hasibul Alam Nafisa Marzan Chowdhury Shanaz Pervin Md Anwar Hossain <p><strong>Background: </strong>Secondhand smoking (SHS) is a major public health problem of our country because the people of Bangladesh are highly exposed to it due to high prevalence of smoking.</p> <p><strong>Objective: </strong>To assess the knowledge, attitude and exposure to secondhand smoking among women in rural setting.</p> <p><strong>Methods: </strong>The cross- sectional study is conducted over 3 months (September 2022 to November 2022) among 383 women of reproductive age (15-49) in Uttar Rampur village under Sadar South Upazilla in Cumilla district. Women having any physical &amp; psychological disorder are excluded. Participants are selected by convenient sampling technique; data are collected by face to face interviewing with a semi-structured questionnaire to assess socio-demographic characteristics, knowledge, attitude and exposure to secondhand smoking. Data are analyzed by SPSS software.</p> <p><strong>Results: </strong>In this study, the mean age of the participants is31.57±7.582 where majority (44.1%) of the participants are in the age group 25-34 years; most of them are Muslims (95.6%) and housewives(87.2%) and 27.2% has secondary education. Regarding knowledge about SHS, majority (67.6%) of the participants are aware of SHS. Among them 37.6% recognize marketplace as a source of SHS and 29.5% tell lung disease as health consequence of SHS. About attitude towards SHS, almost all (98.5%) the participants support that smoking should be completely banned in all places, 88.4% tell about right to ask other people not to smoke, 87.3% tell about presence of SHS encourages young peopleto begin to smoke and 79.2% tell about allowing SHS athome discourages smoking from quitting. Regarding exposure to SHS, most of them are exposed (95.0%)&nbsp; and 46.7% are exposed daily. 53.6% are exposed from husband and manufactured tobacco is widely exposed type (69.5%).</p> <p><strong>Conclusion:</strong> Awareness should be raised through national wide educational program to reduce exposure to secondhand smoke and enhancement of self-efficiency to avoid secondhand smoking.</p> <p>Central Medical College Journal Vol 7 No 1 January 2023 Page: 26-31</p> 2024-01-21T00:00:00+00:00 Copyright (c) 2023 Central Medical College Journal Unveiling the Burden of Osteoporosis: Exploring the Prevalence and Risk Factors among Postmenopausal Women in North Central Bangladesh. 2024-01-10T15:51:03+00:00 Md Salehin Kha Md Golam Kibria Farhana Hossain Jannatul Ferdous Hossain Mohammad Shihab Shah Mohammad Faisal <p><strong>Background: </strong>Osteoporosis affects 30% of women globally between the ages of 40 and 50. This disease is among the top causes of death and disability among the elderly. This study aimed to examine the prevalence of primary osteoporosis and poor bone density in postmenopausal women, as well as their socio demographic, obstetric, and lifestyle risk factors.</p> <p><strong>Aim: </strong>The purpose of this study is to investigate at the prevalence of osteoporosis and the risk factors linked with it in postmenopausal women.</p> <p><strong>Methods: </strong>The present prospective cross-sectional study was conducted on postmenopausal women who visited orthopedics, gynecology, and medicine outpatient departments between August 2022 and March 2023; 539 women aged 45 to 80 years with verified menopause were recruited. The final recommendation was for 539 women to have bone mineral density testing utilizing dual energy X-ray absorptiometry. Socio-individual, obstetric-medical, short-form physical activity, and anthropometric questionnaires were administered. Chi-square and Student's t-tests were applied to categorical and continuous data, respectively, to assess the differences between the groups. In SPSS 26, P&lt;0.05 was regarded to indicate significant connections.</p> <p><strong>Results: </strong>In our study, 38.0% of participants were between<br />56 and 60 years of age. The majority of the individuals (51.9%) were illiterate. 37.7% of respondents reported having six or more children. 3.6% of the sample smoked or chewed tobacco. 61.0 percent of individuals had menopause after the age of 45, and 48.8% of subjects had experienced menopause for more than ten years at the time of enrollment in the research. 83.5% of postmenopausal women were affected by osteoporotic fractures (osteoporosis: 40.0% and osteopenia: 43.5%). The incidence of osteoporosis rose as parity and abortion rates increased. The prevalence of osteoporosis was greater (P&lt; 0.05) among those with a familial history of osteoporosis-related symptoms and fragility fracture, as well as a personal history of fragility fracture.</p> <p><strong>Conclusion: </strong>Given the significant prevalence of primary osteoporosis and poor bone density in postmenopausal women, health education is essential for minimizing modifiable risk factors and mitigating the disease's consequences. </p> <p>Central Medical College Journal Vol 7 No 1 January 2023 Page: 32-40</p> 2024-01-21T00:00:00+00:00 Copyright (c) 2023 Central Medical College Journal Evaluation the role of supplementation of oral zinc on systolic and diastolic blood pressure in type 2 diabetic patients 2024-01-10T16:12:46+00:00 Sharmin Khan Md Saiful Ahsan Rana Mohammad Fazlul Haque Shomia Farid Tanni Sabira Tabassum <p><strong>Background: </strong>Zinc is an important trace element and a potent antioxidant. Its deficiency causes a common comorbidity with numerous chronic diseases including hypertension and diabetes mellitus, associated with development and progression of various complications.</p> <p><strong>Objective: </strong>The present study has been undertaken to evaluate the effects of zinc supplementation on blood pressure in type 2 diabetic patients.</p> <p><strong>Methods: </strong>This prospective interventional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka between January 2016 to December 2016. In this study, a total number of 46 diagnosed type 2 diabetic patients of both sexes were selected with age ranging from 40 to 55 years. Among them, 26 type 2 diabetic patients with supplementation of oral zinc (40mg/day) for 12 weeks were considered as study group (Group B). Another 25 age matched type 2 diabetic patients without supplementation of oral zinc were considered as control group (Group A) for comparison. All subjects were selected from Outpatient Department of Endocrinology, Dhaka Medical College Hospital, Dhaka on the basis of inclusion and exclusion criteria. Their blood pressure (BP) was measured and serum zinc level was estimated by Spectrophotometric method accordingly. These parameters were studied 2 times in all subjects of control and study groups i.e. at the beginning of study (base line) and after 12 weeks of study period. Data were collected in pre-designed structured questionnaire form by the researcher herself. For statistical analysis, paired Student’s ‘t’ test and unpaired Student’s ‘t’ test were performed as applicable using SPSS for windows version 22.0.</p> <p><strong>Results: </strong>In this study, after zinc supplementation resulted in a significant (p&lt;0.001) decrease in both systolic and diastolic blood pressure in study group but there was no significant change observed in control group.</p> <p><strong>Conclusions: </strong>After analyzing the results of the study, it can be concluded that oral zinc supplementation can be useful for improving blood pressure in type 2 diabetic patients. </p> <p>Central Medical College Journal Vol 7 No 1 January 2023 Page: 41-46</p> 2024-01-21T00:00:00+00:00 Copyright (c) 2023 Central Medical College Journal Exploring the Prevalence, Risk Factors and Association with Physical Activity of Musculoskeletal Disorders among Patients Attending a Tertiary Teaching Hospital in Gazipur Bangladesh: A Cross-Sectional Study 2024-01-10T17:08:40+00:00 Md Salehin Kha Md Golam Kibria Farhana Hossain Jannatul Ferdous Hossain Mohammad Shihab <p><strong>Background: </strong>Musculoskeletal disorders encompass a range of strain-related conditions affecting the musculoskeletal system. Physical activity has been recognized as a protective factor against numerous disabling diseases, including musculoskeletal disorders. This study aims to examine the prevalence of musculoskeletal disorders and investigate its correlation with physical activity in the context of Bangladesh.</p> <p><strong>Methods: </strong>This cross-sectional study employed a robust methodology involving the use of standardized questionnaires to assess physical activity levels and musculoskeletal symptoms among 430 patients attending outpatient departments at Gazipur City Medical College. The study period spanned from December 2022 to March 2023, facilitating the collection of valuable data for analyzing the relationship between physical activity and musculoskeletal disorders in this specific population.</p> <p><strong>Results: </strong>The study included 430 individuals, with a fairly equal distribution between males (41.9%) and females (58.1%). The majority fell within the 31-40 age range (34.9%). About 42.0% were overweight, while 39.0% had a normal weight. Urban residents constituted 69.8%, and the predominant occupational groups were office workers (23.3%) and garments workers (27.9%). Approximately 60.5% reported co-morbidities, and sedentary behavior was prevalent (70.0% sat for &lt;4 hours). Lower back pain (52.56%) and knee pain (64.19%) were most commonly reported, impacting work for 32.89% and 46.71% of individuals, respectively. Significant associations were found between physical activity level and pain in multiple body regions. Lower physical activity levels were associated with a higher prevalence of pain. These findings emphasize the importance of promoting higher physical activity levels to reduce musculoskeletal pain.</p> <p><strong>Conclusion: </strong>This study highlights the significant prevalence of musculoskeletal disorders (MSDs) and their impact on work among individuals attending outpatient departments. Promoting higher physical activity levels is crucial for reducing musculoskeletal pain and improving occupational outcomes</p> <p>Central Medical College Journal Vol 7 No 1 January 2023 Page: 47-56</p> 2024-01-21T00:00:00+00:00 Copyright (c) 2023 Central Medical College Journal