Incidence, Epidemiology and Clinico-Pathological Status of Different Molecular Subtypes of Breast Cancer in NICRH, Dhaka

Abstract

Background: Molecular subtype determination of breast carcinoma is still an enigma in our perspective. We are far behind the genetic analysis but immunohistochemistry is commonly ensured now a days.

Objective: To observe the incidence, epidemiological and clinico-pathological status of different molecular subtypes of breast cancer patients.

Materials and method: At first 141 patients were enrolled by purposive sampling. Among them 138 patients were finalized according to the eligibility criteria. A pre-structured, peer reviewed, properly tested, interview and observation based data collection sheet was prepared. Data regarding epidemiological profile, clinical profile and histopathological profile were collected, compiled, edited and analyzed. Mean, frequency, chi-square test were adopted for analysis. Statistics were found significant at <0.05.

Results: Mean age of patients was 43.20±9.69 years. Mean BMI was 25.26±13.47. Out of 138 patients, only 4.34% had positive family history, 64.49% and 35.5% had left and right sided breast cancer respectively, 65.2% had tumour size 2-5cm which was followed by 27.53% cases with >5cm sized tumour in maximum diameter. Among the five major molecular subtypes both luminal A and triple negative breast cancer (TNBC) showed high prevalence (27.53%). Association of molecular subtypes with histopathological grading revealed TNBC was the most aggressive among all molecular subtypes. Axillary lymphadenopathy was present in almost all cases.

Conclusion: Luminal A and TNBC were positive in most of the cases whereas TNBC showed higher association with advance histopathological grade. Clinical status was almost similar in all subtypes.

Delta Med Col J. Jan 2018 6(1): 9-17