Induction Chemotherapy for Advanced Head and Neck Cancer Patients: Outcomes of A Quasi-Experimental Study.

Authors

  • Md Nizamul Haque Associate Professor & Head, Department of Radiotherapy, Faridpur Medical College, Faridpur
  • ASM Jahangir Chowdhury Professor of Orthopaedics and Principal, Faridpur Medical College, Faridpur
  • Md Yusuf Ali Professor & Head of Department of Medicine, Faridpur Medical College, Faridpur
  • Nripendra Nath Biswas Asstt. Professor & Head, Department of ENT, Faridpur Medical College, Faridpur
  • Md Shafiqur Rahman Senior Consultant, Department of ENT, Faridpur Medical College Hospital, Faridpur
  • Swapan Kumar Biswas Asstt. Professor, Department of Surgery, Faridpur Medical College, Faridpur
  • Md Maiyeen Uddin Senior Consultant (Orthopaedic surgery), General Hospital, Faridpur

DOI:

https://doi.org/10.3329/fmcj.v11i2.32885

Keywords:

Head and Neck Cancer, Squamous Cell Carcinoma, Concurrent Chemoradiotherapy, Induction Chemotherapy, Paclitaxel, Cisplatin, Primary Response

Abstract

A quasi experimental study was conducted on outcomes of Induction Chemotherapy for advanced head and neck cancer patients from October 2015 to September 2016 at Faridpur Medical College Hospital, Faridpur. A total of 40 patients with Stages T3/T4, N0-N3, M0 and histological proved Squamous cell carcinoma of the head & neck (SCCHN) were selected to receive three cycles of chemotherapy prior to loco-regional primary concurrent chemoradiotherapy (CCRT). The induction chemotherapy regimen was a combination of Inj. paclitaxel and Inj cisplatin. The primary end point of study was clinical outcome of the patients. The response rate to induction chemotherapy was 55% for the primary tumor (CR: 12% and PR: 43%). Complete disappearance of the primary tumor occurred more often than that of the lymph node metastases. The response rate to induction chemotherapy for lymph node metastases was 24% (CR: 10% and PR: 14 %).

Faridpur Med. Coll. J. Jul 2016;11(2): 54-57

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Author Biography

Md Nizamul Haque, Associate Professor & Head, Department of Radiotherapy, Faridpur Medical College, Faridpur



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Published

2017-06-09

How to Cite

Haque, M. N., Chowdhury, A. J., Ali, M. Y., Biswas, N. N., Rahman, M. S., Biswas, S. K., & Uddin, M. M. (2017). Induction Chemotherapy for Advanced Head and Neck Cancer Patients: Outcomes of A Quasi-Experimental Study. Faridpur Medical College Journal, 11(2), 54–57. https://doi.org/10.3329/fmcj.v11i2.32885

Issue

Vol. 11 No. 2 (2016)

Section

Original Articles